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Effect of depletion of FABP4 in mice intestinal epithelial cells on gene expression

ABSTRACT: Effect of depletion of FABP4 in mice intestinal epithelial cells on gene expression

PROVIDER: PRJNA827777 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18791100.fastq.gz	Fastqsanger.gz
	SRR18791101.fastq.gz	Fastqsanger.gz

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Effect of depletion of FABP4 in mice intestinal epithelial cells on gene expression

Project description:To investigate the function of FABP4 in the intestinal in vitro cultured organoids,FABP4, which located in crypt lyszyme+ Paneth cells can regulate the expression of defensins, especially HFD-mediated downregulation of defensin in Paneth cells will provide insights into factor(s) underlying modern diseases. We then performed gene expression profiling analysis using data obtained from RNA-seq of FABP4fl/flpvillinCreT (FABP4KO) mice and FABP4fl/fl (WT)mice in vitro cultured intestinal organoids.

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