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Metformin promotes in vitro maturation of oocytes from aged mice

ABSTRACT: Metformin promotes in vitro maturation of oocytes from aged mice

PROVIDER: PRJNA828407 | ENA |

REPOSITORIES: ENA

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Metformin promotes in vitro maturation of oocytes from aged mice

Project description:Our study demonstrates a protective effect for metformin against the decreased quality of aged oocytes to potentially improve ART success rates and illustrates a potential strategy to prevent or delay reproductive aging.

2023-04-20 | GSE201098 | GEO

Quercetin promotes in vitro maturation of oocytes from humans and aged mice

Project description:The flavonol compound quercetin is considered to be an anti-aging agent due to its cytoprotective actions as an antioxidant. The RNA sequencing analysis of oocytes after in vitro maturation from aged mice identified many genes altered by quercetin treatment and suggested that such treatment has a pronounced impact on genetic programs associated with mitochondrial dysfunction.

2020-11-24 | GSE157212 | GEO

Quercetin promotes in vitro maturation of oocytes from humans and aged mice

Project description:Quercetin promotes in vitro maturation of oocytes from humans and aged mice

| PRJNA660451 | ENA

Porcine oocytes maturation in vitro

Project description:The proper mammalian oocytes maturation is recognized as reaching MII stage and accumulation of mRNA and proteins in cell cytoplasm following fertilization. The proper course of folliculogenesis and oogenesis is orchestrated with morphogenesis significantly influencing further zygote formation and embryos growth. This study was aimed to determinate new transcriptomic markers of porcine oocytes morphogenesis associated with cell maturation capacity. We used microarrays to detail the global programme of gene expression underlying changes before and after in vitro maturation of oocytes in sus scrofa

2017-03-31 | GSE97246 | GEO

Transcriptomes of human oocytes during in vitro maturation

Project description:We aimed to reveal gene expression profiles of human oocytes at each maturation stage by single cell RNA-seq analyses. We investigated transcriptomes of immature oocytes at the germinal vesicle (GV) stage, maturating oocytes at the metaphase I (MI) stage and in vitro matured oocytes at the metaphase II (MII) stage.

2022-05-09 | GSE166533 | GEO

Transcriptomes of human oocytes during in vitro maturation

Project description:Transcriptomes of human oocytes during in vitro maturation

| PRJNA701233 | ENA

Metformin suppressed maturation of human visceral preadipocytes in vitro with upregulation of miR-1246 and miR-3687

Project description:Metformin suppressed maturation of human visceral preadipocytes in vitro with upregulation of miR-1246 and miR-3687

2015-10-01 | GSE61907 | GEO

Single-cell quantitative proteomic analysis of oocyte maturation revealed high heterogeneities in human in vitro matured oocytes

Project description:In this study we investigated the protein expression patterns during human oocyte in vitro and in vivo maturation (IVO) by single-cell quantitative proteomic analysis of 36 human oocytes. Among 2,094 proteins quantified in 34 oocytes (GV: 11 oocytes, IVM: 12 oocytes, IVO: 11 oocytes), 224 were differential between IVO and GV oocytes during in vivo maturation, and 61 between IVM and IVO oocytes.

2022-08-02 | PXD023366 | Pride

Impact of maternal age and in vitro maturation on the transcriptome of denuded human oocytes

Project description:While the oocytes’ transcriptome is predominantly determined by maturation stage, transcripts related to specific pathways such as chromosome segregation, mitochondria and RNA processing are affected by age after in vitro maturation of denuded oocytes.

2021-03-24 | GSE158802 | GEO

Transcriptomics reveals molecular differences in equine oocytes vitrified before and after in vitro maturation

Project description:The aim of this study was to analyze transcriptome profiles with RNA sequencing (RNA-seq) in metaphase II horse oocytes after vitrification before and after in vitro maturation (IVM). To do so, transcriptome profile of three groups were compared: (1) oocytes vitrified immature, warmed, and in vitro matured (VGV), (2) in vitro matured and vitrified (VMAT), and (3) fresh oocytes (CONTROL).

2023-05-03 | GSE225950 | GEO

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