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Transcriptomic analysis of peripheral blood mononuclear cells (PBMC) in psoriasis patients treated with guselkumab

ABSTRACT: Transcriptomic analysis of peripheral blood mononuclear cells (PBMC) in psoriasis patients treated with guselkumab

PROVIDER: PRJNA831443 | ENA |

REPOSITORIES: ENA

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Transcriptomic analysis of peripheral blood mononuclear cells (PBMC) in psoriasis patients treated with guselkumab

Project description:Psoriasis is a worldwide chronic inflammatory skin disease. The treatment is usually designed according to its severity. In this research, RNA-seq was performed on the peripheral blood mononuclear cells (PBMCs) of 12 patients with psoriasis before and after treatment (4 week) of guselkumab.

2022-04-27 | GSE201397 | GEO

Peripheral blood transcriptome profiles derived from parallel venipuncture (PAXgene and mononuclear cell; PBMC) and dried blood spot (DBS) samples.

Project description:Comparison of transcript abundance estimates and bioinformatic inferences derived from DBS vs PAXgene vs peripheral blood mononuclear cell (PBMC) samples.

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Transcription profiling of human peripheral blood mononuclear (PBMC) cells in pulmonary arterial hypertension

Project description:Microarray analysis of peripheral blood mononuclear (PBMC) cells in pulmonary arterial hypertension.

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Transcriptome profiling of peripheral blood mononuclear cell subsets

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Gene expression changes in Peripheral Blood Mononuclear cells (PBMC) induced by physical activity

Project description:Gene expression changes in Peripheral Blood Mononuclear cells (PBMC) induced by physical activity was investigated in sedentary middle-aged men (mean age 52.6 years and BMI 29.1) who undertook a 24-week physical activity programme with blood sampling in the pre-exercise period , at the end of 24-weeks prescribed physical activity , and following a two-week detraining period. AgilentTM Whole Human Genome Oligo Microarrays were utilised to examine the effects of physical activity on mRNA expression profiles of the Peripheral Blood Mononuclear cells (PBMC) at 3 time points (pre-exercise, after 24 weeks physical activity, and at 26 weeks after 2 weeks detraining. There were 12 participants in this programme.

2010-08-03 | E-GEOD-12385 | biostudies-arrayexpress

Gene expression changes in Peripheral Blood Mononuclear cells (PBMC) induced by physical activity

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Identification of Mineralocorticoid receptor targets in peripheral blood mononuclear cells (PBMC)

Project description:Identification of Mineralocorticoid receptor targets in peripheral blood mononuclear cells (PBMC)

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Transcriptional Profiles in Peripheral Blood Mononuclear Cells - PBMC - from individual controls for Type 2 Diabetes Mellitus

Project description:The oligo microarrays were used to determine gene expression profiles of Peripheral Blood Mononuclear Cells (PBMC) from health individuals.

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Ex vivo treatment of peripheral blood mononuclear cells (PBMC) with L-sulforaphane

Project description:Ex vivo treatment of peripheral blood mononuclear cells (PBMC) with L-sulforaphane

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The Impact of Blood-Processing Time on the Proteome of Human Peripheral Blood Mononuclear Cells

Project description:Human peripheral blood mononuclear cells (PBMC) are key to several diagnostics assays and basic science research. Blood pre-analytical variations that occur before obtaining the PBMC fraction can have a significant impact on the results of the assays, including viability, composition, integrity, and gene expression changes of immune cells. With this as motivation, we performed a quantitative shotgun proteomics analysis using Isobaric Tag for Relative and Absolute Quantitation (iTRAQ 8plex) labeling to compare PBMC obtained from fresh versus 24h-stored blood at room temperature. We identified 3,195 proteins, of which 245 were differentially abundant. Our results revealed enriched pathways in the fresh-PBMC samples related to exocytosis, localization, vesicle-mediated transport, cell activation, and secretion. In contrast, pathways related to exocytosis, neutrophil degranulation and activation, granulocyte activation, leukocyte degranulation, and myeloid leukocyte activation involved in immune response were enriched in the 24h-PBMC samples, which may indicate probable granulocyte contamination and activation due to blood storage time and temperature. Examples of upregulated proteins in the 24h-PBMC sample are: CAMP, S100A8, LTA4H, RASAL3, and S100A6, which are involved in an adaptive immune system and antimicrobial activity, proinflammatory mediation, aminopeptidase activities, and naïve T cells survival. Moreover, examples of downregulated proteins are: NDUFA5, TAGLN2, H3C1, TUBA8, and CCT2 that are related to the cytoskeleton, cell junction, mitochondrial respiratory chain. In conclusion, blood-processing time directly impacts the proteomic profile of human PBMC.

2020-12-14 | PXD021367 | Pride

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