Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Deficiency of Irx5 protects mice from obesity and associated metabolic abnormalities

ABSTRACT: Deficiency of Irx5 protects mice from obesity and associated metabolic abnormalities

PROVIDER: PRJNA832808 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18959141_1.fastq.gz	Fastqsanger.gz
	SRR18959141_2.fastq.gz	Fastqsanger.gz
	SRR18959142_1.fastq.gz	Fastqsanger.gz
	SRR18959142_2.fastq.gz	Fastqsanger.gz
	SRR18959143_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Deficiency of Irx5 protects mice from obesity and associated metabolic abnormalities

Project description:Here we aim to decipher the actions of Irx5 in the regulation of obesity and metabolic abnormalities. We employed a mouse model homozygous for an Irx5-knockout (Irx5KO) allele and conducted droplet based single-cell RNA sequencing (Drop-seq) in the hypothalamic arcuate-median eminence (ARC-ME), which is the main control center for sensing and integrating feeding regulatory signals.

2022-09-19 | GSE201736 | GEO

Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology

Project description:Analysis of the roles of Irx3 and Irx5 transcription factors in mouse heart development and postnatal heart function. Results show that show that Irx3 and Irx5 have redundant function in the in the endocardium to regulate atrioventricular canal morphogenesis and outflow tract formation. A postnatal deletion of Irx3 and Irx5 surprisingly results in a restoration of the repolarization gradient that is altered in Irx5 mutant hearts, suggesting a model whereby postnatal Irx3 activity is normally repressed by Irx5. 4 genotypes were analyzed: Irx5+/- (3 samples), Irx3-/-;Irx5+/- (4 samples), Irx5-/- (3 samples), Irx5-/-;Irx3-/- (4 samples). The Irx5+/- samples are the reference.

2012-06-19 | E-GEOD-38826 | biostudies-arrayexpress

Circular chromatin conformation capture (4C-seq) experiments for viewpoints on the promoters of Rpgrip1l/Fto, Irx3, Irx5 and Irx6 in mouse hypothalamus

Project description:We performed 4C to analyze long-range interactions between the promoters of Rpgrip1l/Fto, Irx3, Irx5 and Irx6 and a region in the first intron of the FTO gene that has been associated with obesity. 3 whole mouse hypothalami were used to obtain the data.

2021-03-20 | E-MTAB-10195 | biostudies-arrayexpress

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

Project description:Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

2020-01-13 | PXD015738 | Pride

IRX5 promotes DNA damage repair and activation of hair follicle stem cells [nhek_d]

Project description:Here, we identify the transcription factor IRX5 as a promoter of HFSC activation. Irx5-/- mice display delayed onset of first postnatal anagen, with increased DNA damage and diminished HFSC proliferation. Through transcriptomic and epigenetic analysis, we discover the formation of open chromatin regions near key cell cycle progression- and DNA damage repair genes in Irx5-/- HFSC. We also identify DNA damage repair factors BRCA1 and BARD1 as IRX5 downstream targets. Inhibition of FGF18 kinase signaling partially rescues the anagen delay in Irx5-/- mice, indicating that the Irx5-/- HFSC quiescent phenotype is in part due to failure to suppress Fgf18 expression. Our findings identify IRX5 as a required promoter of DNA damage repair in HFSC activation and hair cycle initiation.

2022-11-01 | GSE202075 | GEO

IRX5 promotes DNA damage repair and activation of hair follicle stem cells [ms_epidermis]

2022-11-01 | GSE201884 | GEO

IRX5 promotes DNA damage repair and activation of hair follicle stem cells (hfsc)

2023-04-05 | GSE202583 | GEO

KDM4B epigenetically protects against obesity and metabolic dysfunction

Project description:KDM4B epigenetically protects against obesity and metabolic dysfunction

| PRJNA397224 | ENA

IRX5 promotes DNA damage repair and activation of hair follicle stem cells [ATAC-Seq]

2022-11-01 | GSE202085 | GEO

Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology

2012-06-20 | GSE38826 | GEO