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Non-productive infection of glial cells with SARS-CoV-2 in hamster organotypic cerebellar slice cultures

ABSTRACT: Non-productive infection of glial cells with SARS-CoV-2 in hamster organotypic cerebellar slice cultures

PROVIDER: PRJNA833474 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18989500_1.fastq.gz	Fastqsanger.gz
	SRR18989500_2.fastq.gz	Fastqsanger.gz
	SRR18989501_1.fastq.gz	Fastqsanger.gz
	SRR18989501_2.fastq.gz	Fastqsanger.gz
	SRR18989502_1.fastq.gz	Fastqsanger.gz

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Non-productive infection of glial cells with SARS-CoV-2 in hamster organotypic cerebellar slice cultures

Project description:The numerous neurological syndromes associated with COVID-19 implicate an effect of viral pathogenesis on neuronal function, yet reports of direct SARS-CoV-2 infection in the brain are conflicting. We used a well-established organotypic brain slice culture to determine the permissivity of hamster brain tissues to SARS-CoV-2 infection. We found levels of live virus waned after inoculation and observed no evidence of cell-to-cell spread, indicating that SARS-CoV-2 infection was non-productive. Nonetheless, we identified a small number of infected cells with glial phenotypes; yet no evidence of viral infection or replication was observed in neurons. Our data corroborates several clinical studies that have assessed patients with COVID-19 and their association with neurological involvement.

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Project description:The numerous neurological syndromes associated with COVID-19 implicate an effect of viral pathogenesis on neuronal function, yet reports of direct SARS-CoV-2 infection in the brain are conflicting. We used a well-established organotypic brain slice culture to determine the permissivity of hamster brain tissues to SARS-CoV-2 infection. We found levels of live virus waned after inoculation and observed no evidence of cell-to-cell spread, indicating that SARS-CoV-2 infection was non-productive. Nonetheless, we identified a small number of infected cells with glial phenotypes; however, no evidence of viral infection or replication was observed in neurons. Our data corroborate several clinical studies that have assessed patients with COVID-19 and their association with neurological involvement.

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