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DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma (RNA sequencing)

ABSTRACT: DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma (RNA sequencing)

PROVIDER: PRJNA833856 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19020900.fastq.gz	Fastqsanger.gz
	SRR19020901.fastq.gz	Fastqsanger.gz
	SRR19020902.fastq.gz	Fastqsanger.gz
	SRR19020903.fastq.gz	Fastqsanger.gz
	SRR19020904.fastq.gz	Fastqsanger.gz

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DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma

Project description:DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma

| PRJNA867702 | ENA

DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma (DNA methylation)

Project description:DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma (DNA methylation)

| PRJNA833397 | ENA

DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma (RNA sequencing)

Project description:Maternal asthma (MA) is among the most consistent risk factors for asthma in her children. Possible mechanisms for this observation are epigenetic modifications in utero that have lasting effects on developmental programs in children of mothers with asthma. To test this hypothesis, we performed differential DNA methylation analyses of 398,186 individual CpG sites in primary bronchial epithelial cells (BECs) from 42 non-asthma controls and 88 asthma cases, including 56 without MA (NMA) and 32 with MA. We used weighted gene co-expression network analysis (WGCNA) of 69 and 554 differentially methylated CpGs (DMCs) that were specific to NMA or MA cases, respectively, compared to controls. WGCNA grouped 66 NMA-DMCs and 203 MA-DMCs into two and five co-methylation modules, respectively. The eigenvector of one MA-associated module (turquoise) was uniquely correlated with 85 genes expressed in BECs and enriched for 36 pathways, 16 of which discriminated between NMA and MA using machine learning. Genes in all 16 pathways were decreased in MA compared to NMA cases (P=7.1x10-3), a finding that replicated in nasal epithelial cells from an independent cohort (P=0.02). Functional interpretation of these pathways suggested impaired T cell signaling and responses to viral and bacterial pathogens. The MA-associated turquoise module eigenvector was additionally correlated with clinical features of severe asthma and reflective of type 2 (T2)-low asthma (i.e., low total serum IgE, fractional exhaled nitric oxide, and eosinophilia). Overall, these data suggest that maternal asthma alters diverse epigenetically-mediated pathways that lead to distinct subtypes of severe asthma in adults including hard-to-treat T2-low asthma.

2022-05-04 | GSE201955 | GEO

DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma (DNA methylation)

2022-05-02 | GSE201872 | GEO

DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-09 | GSE210843 | GEO

DNA Methylation Profiles of Airway Epithelial Cells and PBMCs from Healthy, Atopic and Asthmatic Children.

Project description:DNA methylation profiling of airway epithelial cells (AECs) and peripheral blood mononuclear cells (PBMCs) from normal, atopic and asthmatic subjects. The Illumina GoldenGate Methylation Cancer Panel I was used to obtain DNA methylation profiles across approximately 1505 CpGs in AECs and PBMCs. Samples included 7 healthy, 9 atopic, 4 atopic asthmatic and 5 non-atopic asthmatic subjects. Please note that only some of the samples are matched (i.e. AECs and PBMCs from the same individual) due to DNA quality or sample collection (i.e. only one sample (AEC or PBMC) was collected from the patient).

2012-05-09 | GSE37853 | GEO

DNA Methylation Profiles of Airway Epithelial Cells and PBMCs from Healthy, Atopic and Asthmatic Children.

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Maternal Asthma During Pregnancy Imprints Fetal Lung Group 2 Innate Lymphoid Cells [snRNA-Seq]

Project description:We investigated the effects on the lungs during fetal in the offspring of asthmatic mothers. Lung ILC2 of offspring of asthmatic mothers altered phenotypically during fetal life.

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Maternal Asthma During Pregnancy Imprints Histone Modification of Lung Group 2 Innate Lymphoid Cells

Project description:We investigated the effects on the lungs during fetal in the offspring of asthmatic mothers. We examined H3K4me3 modification of ILC2 in the adult lungs of offspring of asthmatic mothers.

2024-12-01 | GSE262949 | GEO

Maternal Asthma During Pregnancy Imprints Fetal Lung Group 2 Innate Lymphoid Cells and Enhances Their Function in Adulthood [scATAC-Seq]

Project description:We investigated the effects on the lungs during fetal in the offspring of asthmatic mothers. ILC2 in the fetal and adult lungs of offspring of asthmatic mothers showed overlapping chromatin accessible altered regions

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