Seasonal transcriptome atlas of 80 neural and peripheral tissues of male and female non-human primate Macaca mulatta
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ABSTRACT:
PROVIDER: PRJNA833937 | ENA |
REPOSITORIES: ENA
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Project description:Rhythms of life on earth are shaped by the seasons. Accordingly, various physiological functions such as hormonal secretion, metabolism, growth, immune function, and reproduction show profound seasonal changes in animals including humans. Morbidity in humans due to cardiovascular disease, influenza, and psychiatric diseases is also seasonally regulated and peaks in winter. However, their underlying molecular bases remain unknown. Non-human primates (NHPs) represent the nearest-to-human alternative and are crucial to understand human physiology and diseases. In this study, we identifed genes that showed seasonal oscillations in the expressions for each of the 80 tissues, including 30 brain regions and 50 peripheral tissues collected every 2 months from male and female NHP rhesus macaques (Macaca mulatta) that were kept under seminatural outdoor conditions. In addition, the seasonal transcriptome partterns can be checked in our web database entitled “Non-Human Primate Seasonal Transcriptome Atlas (NHPSTA)”. The overall study contributes to our understanding of the molecular basis for seasonally regulated physiological mechanisms and provides potential biomarkers and targets for developing novel therapeutic intervention for seasonally regulated diseases.
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Project description:Transposable elements (TE) account for more than 50% of human genome. It has been reported that some types of TEs are dynamically regulated in the reprogramming of human cell lines. However, it is largely unknown whether some TEs in Macaca mulatta are also regulated during the reprogramming of cell lines of monkey. Here, we systematically examined the transcriptional activities of TEs during the conversion of Macaca mulatta fibroblast cells to neuroepithelial stem cells (NESCs). Hundreds of TEs were dynamically regulated during the reprogramming of Macaca mulatta fibroblast cells. Furthermore, 60 Long Terminal Repeats (LTRs), as well as some integrase elements, of MacERV3 were transiently activated during the early stages of the conversion process. These LTRs were potentially bound by critical transcription factors for reprogramming, such as KLF4 and ETV5. These results suggest that the transcription of TEs are delicately regulated during the reprogramming of Macaca mulatta fibroblast cells. Although the family of ERVs activated during the reprogramming of fibroblast cells in Macaca mulatta are different from those in the reprogramming of human fibroblast cells, our results suggest that the activation of some ERVs is a conserved mechanism in primates for converting fibroblast cells to stem cells.
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Project description:Aging is a major risk factor for various forms of disease. An enhanced understanding of the physiological mechanisms related to aging is urgently needed. Nonhuman primates (NHPs) have the closest genetic relationship to humans, making them an ideal model to explore the complicated aging process. Multiomics analysis of NHP peripheral blood offers a promising approach to evaluate new therapies and biomarkers. Here, we explored the mechanisms of aging using proteomics (serum and serum-derived exosomes [SDEs]) in rhesus monkey (Macaca mulatta) blood.
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