Project description:Here we perform massively parallel single-cell RNA sequencing (scRNA-seq) of human retinas using two independent platforms, and report the single-cell transcriptomic atlas of the human retina. Using a multi-resolution network-based analysis, we identify all major retinal cell types, and their corresponding gene expression signatures.

2019-09-21 | GSE137537 | GEO

Single-cell Transcriptomic Atlas of the Human Retina Identifies Cell Types Associated with Age-Related Macular Degeneration [Seq-Well]

2019-09-23 | GSE137846 | GEO

Single cell transcriptomic analysis of human tissue (Retina and RPE/Choroid)

Project description:Human retina and RPE/choroid from healthy and age-related macular degeneration donors

2024-01-18 | GSE230348 | GEO

A multi-omics atlas of the human retina at single-cell resolution

Project description:Cell types in the human retina are highly heterogeneous with their abundance varies by several orders of magnitude. To decipher the complexity of gene expression and regulation of the human retinal cell types, we generated a multi-omics single-cell atlas of the adult human retina, including over 250K nuclei for single-nuclei RNA-seq and 150K nuclei for single-nuclei ATAC-seq. Over 60 cell subtypes have been identified based on their transcriptomic profiles, reaching a sensitivity of 0.01%. Integrative analysis of this single-cell multi-omics dataset identified gene regulatory elements across the genome for each cell subtype. In addition, when combined with other data modalities, such as eQTL, potential causal variants can be identified through fine mapping. Taken together, this new dataset represents the most comprehensive single-cell multi-omics profiling for the human retina that enables in-depth molecular characterization of most cell subtypes.

2023-03-14 | GSE226108 | GEO

Single cell of human retina

Project description:Retinal RNA profiles from macula and periphery of each eye were generated by single-cell sequencing. M11-M14 are macula retina and P11-P14 are peripheral retina from the same 78 year old donor. M21-M24 are macula retina and P21-P24 are peripheral retina from the same 90-year-old donor.

2021-08-11 | GSE155288 | GEO

Single cell transcriptomic analysis of human axioloids

Project description:Single cell transcriptomic analysis of human axioloids

| PRJNA820750 | ENA