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Dorsal hippocampal transcriptome analysis after Auditory Fear Conditioning and pharmacological GR modulation

ABSTRACT: Dorsal hippocampal transcriptome analysis after Auditory Fear Conditioning and pharmacological GR modulation

PROVIDER: PRJNA835100 | ENA |

REPOSITORIES: ENA

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Dorsal hippocampal transcriptome analysis after Auditory Fear Conditioning and pharmacological GR modulation

Project description:Aim: We investigated the role of GR in Auditory Fear Conditioning memory consolidation by application of a pharmacological filter using selective glucocorticoid receptor modulators. Methods: Adult male mice were exposed to Auditory Fear Conditioning training and subsequently injected with 3.0 mg/kg corticosterone, 20 mg/kg CORT108297, 80 mg/kg CORT118335, 40 mg/kg RU486 or vehicle. Dorsal hippocampi were dissected 3 hours after injection and snap-frozen. Total RNA was isolated and send for 100bp paired-end sequencing by BGI.

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