Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [childhool scRNA-seq]

ABSTRACT: Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [childhool scRNA-seq]

PROVIDER: PRJNA836319 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

Project description:Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

| PRJNA836317 | ENA

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [SC-islet_snATAC]

Project description:Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [SC-islet_snATAC]

| PRJNA836326 | ENA

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [Adult-snRNA-seq]

Project description:Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [Adult-snRNA-seq]

| PRJNA836322 | ENA

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [CDX1 snRNA-seq]

Project description:Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [CDX1 snRNA-seq]

| PRJNA836320 | ENA

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [Childhood snATAC-seq]

Project description:Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [Childhood snATAC-seq]

| PRJNA836329 | ENA

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [Childhool snRNA-seq]

Project description:Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [Childhool snRNA-seq]

| PRJNA836328 | ENA

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [CDX2 ChIP-seq]

Project description:Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [CDX2 ChIP-seq]

| PRJNA836321 | ENA

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [SC-islet scRNA-seq]

Project description:Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [SC-islet scRNA-seq]

| PRJNA836327 | ENA

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [SC-islet snRNA-seq]

Project description:Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [SC-islet snRNA-seq]

| PRJNA836325 | ENA

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [SC-islet_snATAC]

Project description:Pancreatic islet cells derived from human pluripotent stem cells hold great promise for modeling and treating diabetes. Differences between stem cell-derived and primary islets remain, but molecular insights to inform improvements are limited. Here, we acquire single-cell transcriptomes and accessible chromatin profiles during in vitro islet differentiation and from primary childhood and adult pancreas for comparison. We delineate major cell types, define their regulomes, and describe spatiotemporal regulatory relationships between transcription factors. CDX2 emerged as a regulator of enterochromaffin-like cells, which we show resemble a previously unrecognized, transient CDX2-expressing β-cell-related population in fetal pancreas, arguing against a non-pancreatic origin as proposed. Furthermore, we observe insufficient activation of signal-dependent transcriptional programs during in vitro β-cell maturation and identify sex hormones as drivers of childhood β-cell proliferation. Altogether, our analysis provides a comprehensive understanding of cell fate acquisition in stem cell-derived islets and a framework for manipulating cell identities and maturity.

2023-03-02 | GSE202498 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data