Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [Breast Tumors]

ABSTRACT: Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [Breast Tumors]

PROVIDER: PRJNA837647 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency

Project description:Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency

| PRJNA837645 | ENA

Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [Xenografts]

Project description:Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [Xenografts]

| PRJNA836641 | ENA

Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [RNAseq-Hs578T]

Project description:Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [RNAseq-Hs578T]

| PRJNA990784 | ENA

Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [Breast Tumors]

Project description:Diabetes commonly affects cancer patients. As a comorbidity, it may modify tumor biology and therapy response. Yet, we still lack an understanding of the diabetes-induced molecular changes in human breast tumors and their implication for therapy. The goal of this study was aimed to identify diabetes induced phenotypes and molecular signatures in breast cancer. Here, we investigated the effect of diabetes on breast cancer biology using a three-pronged approach that included analysis of orthotopic human tumor xenografts, patient tumors, and breast cancer cells exposed to diabetes and hyperglycemia. Diabetes and hyperglycemia induced a mesenchymal and stem cell-like phenotypes. Further Diabetes and hyperglycemia also associated with oxidative stress and both gene expression and mutational signatures of DNA repair deficiency. Breast cancer cells cultured under hyperglycemia acquired increased DNA damage and sensitivity to DNA damage response inhibitors. Based on these observations, diabetes-associated breast tumors may show an increased drug response to DNA repair pathway inhibitors that are cancer therapeutics.

2023-11-07 | GSE202922 | GEO

Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [Xenografts]

2023-11-07 | GSE202599 | GEO

Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [MDAMB157 cell lines]

Project description:Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [MDAMB157 cell lines]

| PRJNA836643 | ENA

Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [RNAseq-Hs578T]

2023-11-07 | GSE236419 | GEO

Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [MDAMB157 cell lines]

2023-11-07 | GSE202598 | GEO

Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [ER positive cell lines]

Project description:Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [ER positive cell lines]

| PRJNA836626 | ENA

Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [CML exposed MDAMB231 cells]

Project description:Diabetes-associated breast cancer has a distinct transcriptome and metabolome and shows DNA repair deficiency [CML exposed MDAMB231 cells]

| PRJNA836636 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data