Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Sex differences in statin response in hypercholesterolemic (Apoe knockout) Four Core Genotypes mice.

ABSTRACT: Sex differences in statin response in hypercholesterolemic (Apoe knockout) Four Core Genotypes mice.

PROVIDER: PRJNA837912 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Sex differences in statin response in hypercholesterolemic (Apoe knockout) Four Core Genotypes mice.

Project description:RNA-sequening of livers from Apoe knockout Four Core Genotypes mice (XX ovaries, XX testes, XY ovaries, XY testes) fed either chow diet or chow diet + simvastatin (0.1g/kg) for 8 weeks.

2022-08-11 | GSE202977 | GEO

Transcription profiling of mouse offspring of crosses between hypercholesterolemic and normocholesterolemic parents LUMC-HKG-ApoE-Atherosclerosis

Project description:Enhanced prenatal fatty streak formation in human fetuses has been associated with maternal hypercholesterolemia. However, the possible roles of maternal genetic background and in utero environment on development of atherosclerosis in adult life have not been unraveled. We generated genetically identical heterozygous apoE-deficient mice offspring with a different maternal background to study the intrauterine effect of maternal genotype and associated hypercholesterolemia on the developing vascular system. As read out for increased atherosclerosis development in adult life, a constrictive collar was placed around the carotid artery to induce lesion formation. A significant increase in endothelial cell activation and damage was detected in the carotid arteries of heterozygous apoE-deficient fetuses with apoE-deficient mothers compared with offspring from wild type mothers, but no fatty streak formation was observed. Postnatally, all carotid arteries revealed normal morphology. In adult offspring with maternal apoE-deficiency, the constrictive collar resulted in severe lesion (9/10) development compared with no to only minor lesions (2/10) in offspring of wild type mothers. Microarray analysis showed no effect of maternal apoE-deficiency on gene expression in adult offspring. We conclude that maternal apoE-deficiency not only affects fetal arteries, but also increases the susceptibility for development of collar-induced atherosclerosis in adult life. Experiment Overall Design: Crossing of hypercholesterolemic female with normocholesterolemic male and vice versa, determination of susceptabilioty to atherosclerosis in offspring

2008-06-14 | E-GEOD-6134 | biostudies-arrayexpress

miRNAs expression profile in ischemic hindlimb muscle of normocholesterolemic (C57) vs hypercholesterolemic (Apoe-/-) mice.

Project description:Using NGS, we report the differential-expression profiling of miRNAs in hypercholesterolemic/atherosclerotic conditions in hindlinb ischemic muscle compare to healthy control mice. Data of total miRNA expression are presented as normalized copy number: read per millions of read (RPM). Hindlimb ischemia was surgicaly induced by feromal artery ablation and the animal was sacrified 1 day after surgery for RNA collection.

2019-05-11 | GSE131002 | GEO

miRNAs expression profile in ischemic hindlimb muscle of normocholesterolemic (C57) vs hypercholesterolemic (Apoe-/-) mice.

Project description:miRNAs expression profile in ischemic hindlimb muscle of normocholesterolemic (C57) vs hypercholesterolemic (Apoe-/-) mice.

| PRJNA542269 | ENA

Offsprings of crosses between hypercholesterolemic and normocholesterolemic parents LUMC-HKG-ApoE-Atherosclerosis

2007-08-08 | GSE6134 | GEO

Statin-induced Myopathy

Project description:We performed a genome-wide association study in pooled DNA samples from patients with severe statin myopathy and persistent symptoms post-therapy versus pooled DNAs from an age-adjusted statin-tolerant group. Affymetrix 100K SNP arrays were used according to the manufacturers instructions with two pools of 19 and 20 statin myopathy patients and two pools of 20 statin-tolerant controls.

2010-07-09 | E-GEOD-17574 | biostudies-arrayexpress

Small RNA sequencing of brain-derived extracellular vesicles from post-mortem brain tissue of controls and Alzheimer's disease patients with different APOE genotypes

Project description:Using a recently optimized method for separation of brain-derived EVs (bdEVs) from post-mortem tissues, we obtained bdEVs of 23 AD patients with different APOE genotypes and 7 controls. RNA was extracted from brain homogenate, an intermediate ("10K") EV fraction, and more purified EVs and subjected to small RNA sequencing. Numerous RNA species varied with AD pathology and APOE genotypes. Dysregulation of some of these molecules has been implicated in amyloid processing, neurodegeneration and metabolic functions. Molecular differences of bdEVs may thus reflect or play a role in modulating AD progression.

2020-10-20 | GSE159541 | GEO

Microarray gene expression profiling of aorta genes of APOE-deficient mice receiving the ACE inhibitor captopril

2009-12-03 | GSE19286 | GEO

Statin-induced Myopathy

2010-07-09 | GSE17574 | GEO

Transcription profiling of mouse aorta genes of APOE-deficient animals receiving the ACE inhibitor captopril

Project description:Microarray gene expression profiling of aorta genes of APOE-deficient mice receiving atherosclerosis treatment with the ACE inhibitor captopril. Hypercholesterolemic APOE-deficient mice were used as a standard model of atherosclerosis to study gene expression changes during atherosclerosis treatment with the ACE inhibitor captopril. Microarray analysis was performed of whole aortas isolated from captopril-treated APOE-deficient mice relative to untreated APOE-deficient mice with overt atherosclerosis, and nontransgenic control mice. Microarray gene expression profiling revealed that captopril-mediated atherosclerosis prevention involved inhibition of aorta-infiltrating immune cells such as pro-atherogenic T lymphocytes and macrophages. Experiment Overall Design: Microarray gene expression profiling was performed of whole aortas isolated from APOE-deficient mice with atherosclerosis relative to captopril-treated APOE-deficient mice, and nontransgenic control mice. Three study groups were analyzed, i.e. 8-months-old untreated APOE-deficient mice with overt atherosclerosis, age-matched APOE-deficient mice treated for 7 months with the angiotensin-converting enzyme (ACE) inhibitor, captopril (20 mg/kg in drinking water), and nontransgenic control C57BL/6J mice. Two biological replicates were made of each group, and total RNA of three aortas was pooled for one gene chip.

2009-12-14 | E-GEOD-19286 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data