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Adipose-derived stromal/stem cells for bio-root regeneration

ABSTRACT: Adipose-derived stromal/stem cells for bio-root regeneration

PROVIDER: PRJNA838139 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19213426_1.fastq.gz	Fastqsanger.gz
	SRR19213426_2.fastq.gz	Fastqsanger.gz
	SRR19213427_1.fastq.gz	Fastqsanger.gz
	SRR19213427_2.fastq.gz	Fastqsanger.gz
	SRR19213428_1.fastq.gz	Fastqsanger.gz

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Adipose-derived stromal/stem cells for bio-root regeneration

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Adipose-derived stromal/stem cells are verified to be potential seed candidates for bio-root regeneration in three-dimensional culture.

Project description:BackgroundBio-root regeneration is a promising treatment for tooth loss. It has been reported that dental-derived stem cells are effective seed cells for bio-root construction, but further applications are limited by their few sources. Human adipose tissues have a wide range of sources and numerous studies have confirmed the ability of adipose-derived stromal/stem cells (ASCs) in regenerative medicine. In the current study, the odontogenic capacities of ASCs were compared with dental-derived stem cells including dental follicle cells (DFCs), and stem cells from human exfoliated deciduous teeth (SHEDs).MethodsThe biological characteristics of ASCs, DFCs, and SHEDs were explored in vitro. Two-dimensional (2D) and three-dimensional (3D) cultures were compared in vitro. Odontogenic characteristics of porcine-treated dentin matrix (pTDM) induced cells under a 3D microenvironment in vitro were compared. The complexes (cell/pTDM) were transplanted subcutaneously into nude mice to verify regenerative potential. RNA sequencing (RNA-seq) was used to explore molecular mechanisms of different seed cells in bio-root regeneration.Results3D culture was more efficient in constructing bio-root complexes. ASCs exhibited good biological characteristics similar to dental-derived stem cells in vitro. Besides, pTDM induced ASCs presented odontogenic ability similar to dental-derived stem cells. Furthermore, 3D cultured ASCs/pTDM complex promoted regeneration of dentin-like, pulp-like, and periodontal fiber-like tissues in vivo. Analysis indicated that PI3K-Akt, VEGF signaling pathways may play key roles in the process of inducing ASCs odontogenic differentiation by pTDM.ConclusionsASCs are potential seed cells for pTDM-induced bio-root regeneration, providing a basis for further research and application.

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