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The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression

ABSTRACT: The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression

PROVIDER: PRJNA838558 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19218000.fastq.gz	Fastqsanger.gz
	SRR19218001.fastq.gz	Fastqsanger.gz
	SRR19218002.fastq.gz	Fastqsanger.gz
	SRR19218003.fastq.gz	Fastqsanger.gz
	SRR19218004.fastq.gz	Fastqsanger.gz

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The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression (CUT&RUN)

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Effects of the long noncoding RNA Malat1 on gene expression

Project description:This SuperSeries is composed of the following subset Series: GSE37705: Effects of the long noncoding RNA Malat1 on gene expression [Mouse430_2] GSE37706: Effects of the long noncoding RNA Malat1 on gene expression [MoEx-1_0-st] Refer to individual Series

2012-06-24 | E-GEOD-37707 | biostudies-arrayexpress

Effects of the long noncoding RNA Malat1 on gene expression [Mouse430_2]

Project description:Malat1 is an abundant long noncoding RNA that localizes to nuclear bodies known as nuclear speckles, which contain a distinct set of pre-mRNA processing factors. Previous in vitro studies have demonstrated that Malat1 interacts with pre-mRNA splicing factors, including the serine- and arginine-rich (SR) family of proteins, and regulates a variety of biological processes, including cancer cell migration, synapse formation, cell cycle progression, and responses to serum stimulation. To address the physiological function of Malat1 in a living organism, we generated Malat1-KO (KO) mice using homologous recombination. Unexpectedly, the Malat1-KO mice were viable and fertile, showing no apparent phenotypes. Nuclear speckle markers were also correctly localized in cells that lacked Malat1. However, the cellular levels of another long noncoding RNA, Neat1, which is an architectural component of nuclear bodies known as paraspeckles, were downregulated in a particular set of tissues and cells lacking Malat1. To address if the the absence of Malat1 affects the expression of other genes, including other long noncoding RNA, microarrays were used to study the impact of knocking-out Malat1 on global gene expression in mouse embryonic fibroblasts (MEFs). MEFs were prepared from E13.5 mouse embryos from wildtype and Malat1 knock-out mice. RNA harvested from these cells were hybridized to Affymetirx mouse gene expression array.

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