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Single cell transcriptome of the mouse larynx

ABSTRACT: Single cell transcriptome of the mouse larynx

PROVIDER: PRJNA839102 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19256370_1.fastq.gz	Fastqsanger.gz
	SRR19256370_2.fastq.gz	Fastqsanger.gz
	SRR19256371_1.fastq.gz	Fastqsanger.gz
	SRR19256371_2.fastq.gz	Fastqsanger.gz
	SRR19256372_1.fastq.gz	Fastqsanger.gz

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Single cell transcriptome of the mouse larynx

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Project description:Purpose: This study seeks to determine the role of Hedgehog signaling in larynx development. Methods: To determine how Hedgehog signaling directs larynx epithelial morphogenesis we used genomic approaches to identify a novel set of Hedgehog target genes within the early larynx. To this end, we performed bulk RNA-seq on 3-pooled E10.5 (32-35S) larynx tissues from wild-type (2 replicates) and Shh-/- (2 replicates) embryos. From this experiment we identified 1873 differentially expressed genes (p-value <0.05). Results: Hedgehog is essential for maintaining the identity of foregut-derived epithelial cells within the larynx vocal folds. In the absence of HH signaling these epithelial cells undergo specific transcriptional changes to initiate a partial epithelial-to-mesenchymal transition, migrate out of the epithelial layer and under go cell death. The layer is then replaced by a different population of cells.

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