Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Lipolysis regulates major transcriptional programs in brown adipocytes [hBA]

ABSTRACT: Lipolysis regulates major transcriptional programs in brown adipocytes [hBA]

PROVIDER: PRJNA839248 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19262373_1.fastq.gz	Fastqsanger.gz
	SRR19262373_2.fastq.gz	Fastqsanger.gz
	SRR19262374_1.fastq.gz	Fastqsanger.gz
	SRR19262374_2.fastq.gz	Fastqsanger.gz
	SRR19262375_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Lipolysis regulates major transcriptional programs in brown adipocytes

Project description:Lipolysis regulates major transcriptional programs in brown adipocytes

| PRJNA837456 | ENA

Lipolysis regulates major transcriptional programs in brown adipocytes

Project description:β-Adrenergic signaling is a core regulator of brown adipocyte function stimulating both lipolysis and transcription of thermogenic genes, thereby expanding the capacity for oxidative metabolism. Here we have used pharmacological inhibitors and a novel direct activator of lipolysis to acutely modulate the activity of lipases, thereby enabling us to uncover lipolysis-dependent signaling pathways downstream of β-adrenergic signaling in brown adipocytes. We show that induction of lipolysis leads to acute induction of several gene programs and is required for transcriptional regulation by β-adrenergic signals. Using machine-learning algorithms to infer causal transcription factors, we show that PPARs are key mediators of lipolysis-induced activation of genes involved in lipid metabolism and thermogenesis. Importantly, lipolysis also activates the unfolded protein response and regulates the core circadian transcriptional machinery independently of PPARs. Our results demonstrate that lipolysis generates important metabolic signals that exert profound pleiotropic effects on brown adipocyte transcription and function.

2022-05-15 | GSE202833 | GEO

Lipolysis regulates major transcriptional programs in brown adipocytes [hBA]

2022-05-21 | GSE203247 | GEO

Lipolysis regulates major transcriptional programs in brown adipocytes [DOX exp]

Project description:Lipolysis regulates major transcriptional programs in brown adipocytes [DOX exp]

| PRJNA843958 | ENA

Lipolysis regulates major transcriptional programs in brown adipocytes [3Dcultured_eWAs_RNA-seq]

Project description:Lipolysis regulates major transcriptional programs in brown adipocytes [3Dcultured_eWAs_RNA-seq]

| PRJNA837459 | ENA

Lipolysis regulates major transcriptional programs in brown adipocytes [DOX exp]

2022-06-03 | GSE205127 | GEO

Lipolysis regulates major transcriptional programs in brown adipocytes [3Dcultured_eWAs_RNA-seq]