Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Integrated multiomic characterization of congenital heart disease [ATAC-Seq]

ABSTRACT: Integrated multiomic characterization of congenital heart disease [ATAC-Seq]

PROVIDER: PRJNA839347 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19266839_1.fastq.gz	Fastqsanger.gz
	SRR19266839_2.fastq.gz	Fastqsanger.gz
	SRR19266840_1.fastq.gz	Fastqsanger.gz
	SRR19266840_2.fastq.gz	Fastqsanger.gz
	SRR19266841_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Integrated multiomic characterization of congenital heart disease

Project description:Integrated multiomic characterization of congenital heart disease

| PRJNA839343 | ENA

Integrated multiomic characterization of congenital heart disease [RNA-Seq]

Project description:Integrated multiomic characterization of congenital heart disease [RNA-Seq]

| PRJNA842850 | ENA

Integrated multiomic characterization of congenital heart disease [RNA-Seq]

Project description:The heart, the first organ to develop, undergoes complex morphogenesis that when defective results in congenital heart disease (CHD). With current therapies, more than 90% of CHD patients survive into adulthood but often suffer premature death from heart failure (HF) and non-cardiac causes 1. To gain insight into poorly understood disease progression, we performed single nuclear RNA sequencing (snRNA-seq) and analyzed more than 157,000 nuclei from donors and CHD patients, including hypoplastic left heart syndrome (HLHS) and Tetralogy of Fallot (TOF), two common forms of cyanotic CHD lesions, as well as, dilated (DCM) and hypertrophic (HCM) cardiomyopathies. We observed CHD specific cell states in cardiomyocytes (CMs) which had evidence of insulin resistance and increased FOXO and CRIM1 expression. Cardiac fibroblasts (CFs) in HLHS had enrichment for a low HIPPO and high YAP cell state characteristic of activated CFs. Imaging Mass Cytometry (IMC) uncovered the spatially resolved perivascular microenvironment consistent with an immunodeficient state in CHD. Peripheral immune cell profiling suggested deficient monocytic immunity in CHD in agreement with CHD predilection to infection and cancer 2. Our comprehensive CHD phenotyping provides a roadmap for future personalized medicine in CHD.

2022-06-22 | GSE203274 | GEO

Integrated multiomic characterization of congenital heart disease [ATAC-Seq]

2022-06-22 | GSE203273 | GEO

Integrated multiomic characterization of congenital heart disease

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-06-22 | GSE203275 | GEO

Proteomic analysis of the umbilical cord in prematurity and congenital heart disease

Project description:Data-independent acquisition (DIA)-based proteome analysis in preterm infants and congenital heart disease infants

2024-12-20 | PXD047992 | JPOST Repository

Array CGH in congenital heart disease

Project description:Congenital heart disease (CHD) is the most frequent birth defect and affects nearly 1% of newborns. The etiology of CHD is largely unknown and only a small percentage can be assigned to environmental risk factors such as maternal diseases or exposure to mutagenic agents during pregnancy. Chromosomal imbalances have been identified in many forms of syndromic CHD, but next to nothing is known about the impact of DNA copy number changes in non-syndromic CHD. Here we present a sub-megabase resolution array CGH screen of a cohort with CHD as the sole abnormality at the time of diagnosis. Keywords: array CGH In this BAC array CGH study 104 patients with congenital heart disease and some of their parents were screened for DNA copy number changes at submegabase resolution. No dye swap was performed.

2008-05-11 | E-GEOD-7527 | biostudies-arrayexpress

Array-CGH in Chinese children with congenital heart disease

Project description:We used Affymetrix CytoScan750K array to detect the pathogenic copy number variations in 7 Chinese children with congenital heart disease

2021-10-01 | E-MTAB-8315 | biostudies-arrayexpress

Developmental Mechanisms of Human Congenital Heart Disease

Project description:Developmental Mechanisms of Human Congenital Heart Disease

| PRJNA380445 | ENA

PCGC: Congenital Heart Disease Genetic Network Study

Project description:PCGC: Congenital Heart Disease Genetic Network Study

| PRJNA183421 | ENA