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Accumulating Oxidative DNA Damage in Reconstituting T-cells is Associated with Disease Relapse and Inferior Survival Following Allo-SCT [RNAseq in vivo]

ABSTRACT: Accumulating Oxidative DNA Damage in Reconstituting T-cells is Associated with Disease Relapse and Inferior Survival Following Allo-SCT [RNAseq in vivo]

PROVIDER: PRJNA842336 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19395039.fastq.gz	Fastqsanger.gz
	SRR19395040.fastq.gz	Fastqsanger.gz
	SRR19395041.fastq.gz	Fastqsanger.gz
	SRR19395042.fastq.gz	Fastqsanger.gz
	SRR19395043.fastq.gz	Fastqsanger.gz

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Accumulating Oxidative DNA Damage in Reconstituting T-cells is Associated with Disease Relapse and Inferior Survival Following Allo-SCT

Project description:Accumulating Oxidative DNA Damage in Reconstituting T-cells is Associated with Disease Relapse and Inferior Survival Following Allo-SCT

| PRJNA842332 | ENA

Accumulating Oxidative DNA Damage in Reconstituting T-cells is Associated with Disease Relapse and Inferior Survival Following Allo-SCT [RNAseq in vitro]

Project description:Accumulating Oxidative DNA Damage in Reconstituting T-cells is Associated with Disease Relapse and Inferior Survival Following Allo-SCT [RNAseq in vitro]

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Accumulating Oxidative DNA Damage in Reconstituting T-cells is Associated with Disease Relapse and Inferior Survival Following Allo-SCT

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-05-01 | GSE204783 | GEO

Accumulating Oxidative DNA Damage in Reconstituting T-cells is Associated with Disease Relapse and Inferior Survival Following Allo-SCT [RNAseq in vivo]

Project description:Oxidative T-cell DNA damage impacts GVL

2024-05-01 | GSE204782 | GEO

Accumulating Oxidative DNA Damage in Reconstituting T-cells is Associated with Disease Relapse and Inferior Survival Following Allo-SCT [RNAseq in vitro]

Project description:Oxidative T-cell DNA damage impacts GVL

2024-05-01 | GSE204781 | GEO

MeDIP-seq of genome-wide methylation state in M-SCT floxed and M-SCT KO inguinal white adipose tissue

Project description:We analysed the DNA methylation patterns of inguinal white adipose tissue in M-SCT floxed and M-SCT KO, the results indicated a significant widepread hypermethylation modification in M-SCT floxed which contributed to the increased obesity susceptibility of M-SCT floxed

2020-12-02 | GSE162406 | GEO

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Project description:Pseudomonas sp. SCT

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scRNA-seq of allo-reactive CD4+ T cells

Project description:Acute graft versus host disease is a serious condition caused by allo-reactive donor CD4+ T cells from allogenic hematopoietic stem cell transplantation. To understand the developmental relationships between T-helper states in mesenteric lymph nodes (mLN), TCR transgenic CD4+ T cells specific for a single allo-peptide (TEa cells) from mice were recovered at Days 0, 1, 2, 3, and 4 from mLN, and Day 5 from the gut and underwent processing to generate scRNA-seq dataset. TEa cells were also recovered at Day 5 from mLN and were either treated with and without IEL-isolation pre-digestion buffer as controls.

2020-06-06 | E-MTAB-9125 | biostudies-arrayexpress

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Project description:The purpose of this study is to evaluate the safety and efficacy of SCT-I10A combined SCT200 or SCT-I10A combined SCT200 plus chemotherapy in advanced esophageal squamous cell carcinoma and colorectal cancer

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Peri-transplant Glucocorticoids Redistribute Donor T-cells to the Bone Marrow and Prevent Relapse after haploidentical SCT

Project description:Patients with acute leukemia who are unable to achieve complete remission prior to allogeneic hematopoietic stem cell transplantation (SCT) have dismal outcomes with relapse rates well in excess of 60%. Haplo-identical SCT (haplo-SCT) may allow enhanced graft-versus-leukemia (GVL) effects by virtue of HLA class I/II donor-host disparities but typically requires intensive immune-suppression with post-transplant cyclophosphamide (PT-Cy) to prevent lethal graft-versus-host disease (GVHD). Here we demonstrate in preclinical models that glucocorticoid administration from day -1 to +5 inhibits alloantigen presentation by professional recipient antigen presenting cells in the gastrointestinal tract and prevents donor T-cell priming and subsequent expansion therein. In contrast, direct glucocorticoid signaling of donor T-cells promotes chemokine and integrin signatures permissive of preferential circulation and migration into the bone marrow, promoting donor T-cell residency.

2021-10-31 | GSE184963 | GEO

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