Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Triplexes are Dynamic DNA Secondary Structures Formed in vivo and Linked to Genome Instability [pacBio WGS]

ABSTRACT: Triplexes are Dynamic DNA Secondary Structures Formed in vivo and Linked to Genome Instability [pacBio WGS]

PROVIDER: PRJNA842381 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19400245_subreads.fastq.gz	Fastqsanger.gz
	SRR19400246_subreads.fastq.gz	Fastqsanger.gz
	SRR19400247_subreads.fastq.gz	Fastqsanger.gz
	SRR19400248_subreads.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Triplexes are Dynamic DNA Secondary Structures Formed in vivo and Linked to Genome Instability [pacBio WGS]

Project description:Numerous indirect, genetic approaches in various experimental systems have implicated dynamic alternative non-B DNA structures in human physiology and disease. Nevertheless, direct detection of dynamic DNA structures in vivo remains a challenge. To address this problem, we developed a new methods to visualize ssDNA containing alternative DNA structures. We described an uncharted landscape of dynamic alternative DNA structures formed by DNA cruciform and DNA triplexes (H-DNA) that contribute to genome instability.

2022-09-01 | GSE204806 | GEO

Triplexes are Dynamic DNA Secondary Structures Formed in vivo and Linked to Genome Instability [END-seq]

2022-09-01 | GSE203632 | GEO

Triplexes are Dynamic DNA Secondary Structures Formed in vivo and Linked to Genome Instability

Project description:Triplexes are Dynamic DNA Secondary Structures Formed in vivo and Linked to Genome Instability

| PRJNA842375 | ENA

Triplexes are Dynamic DNA Secondary Structures Formed in vivo and Linked to Genome Instability [END-seq]

Project description:Triplexes are Dynamic DNA Secondary Structures Formed in vivo and Linked to Genome Instability [END-seq]

| PRJNA841652 | ENA

LarScl-PacBio-WGS

Project description:Larinioides sclopetarius PacBio genomic data

| PRJEB74310 | ENA

Triplexes are Dynamic DNA Secondary Structures Formed in vivo and Linked to Genome Instability

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-09-01 | GSE204808 | GEO

RNA-seq (Illumina and PacBio) of hESC

Project description:We used PacBio data to identify more reliable transcripts from hESC, based on which we can estimate gene/transcript abundance better from Illumina data. PacBio long reads and Illumina short reads were generated from the same hESC cell line H1. PacBio reads were error-corrected by Illumina reads to identify transcripts. rSeq is used to estimate gene/transcript abundance of the identified transcriptome.

2013-10-30 | E-GEOD-51861 | biostudies-arrayexpress

Werner Helicase Prevents Cell Death in Cancers with Microsatellite Instability [PacBio]

Project description:Werner Helicase Prevents Cell Death in Cancers with Microsatellite Instability [PacBio]

| PRJNA645165 | ENA

Transcription dynamics prevents RNA-mediated genomic instability through SRPK2-dependent DDX23 phosphorylation

Project description:Genomic instability is frequently caused by nucleic acids structures formed during transcription termed R-loops. Despite their harmful potential, mechanisms that sense, signal and suppress these structures remain elusive. Here we report that oscillations in transcription dynamics are a major sensor of R-loops. We show that pausing of RNA polymerase II (RNA Pol II) initiates a signaling cascade whereby the serine/arginine protein kinase 2 (SRPK2) phosphorylates the DDX23 helicase culminating in the suppression of R-loops. We show that in the absence of either SRPK2 or DDX23, accumulation of R-loops leads to massive genomic instability revealed by high levels of DNA double-strand breaks (DSBs). Importantly, we found DDX23 mutations in several cancers and detected homozygous deletions of the entire DDX23 locus in 10 (17%) adenoid cystic carcinoma samples. Our results unravel molecular details of a novel link between transcription dynamics and RNA-mediated genomic instability that may play important roles in cancer development.

2016-12-22 | GSE76777 | GEO

PacBio Sequel WGS of Tursiops Aduncus

Project description:PacBio Sequel WGS of Tursiops Aduncus

| PRJEB29382 | ENA