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Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [hMeDIP]

ABSTRACT: Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [hMeDIP]

PROVIDER: PRJNA842659 | ENA |

REPOSITORIES: ENA

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Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [hMeDIP]

Project description:To investigate the associated with abnormal DNA demethylation and neural tube defects (NTDs) with folate deficiency, we etablished mouse embryonic stem cells (mESCs) Sv/129 in folate-deficiency-treated.

2022-09-20 | GSE204870 | GEO

Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [MeDIP]

2022-09-20 | GSE204872 | GEO

Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [ChIP-seq]

Project description:To investigate the associated with DNA demethylation and neural tube defects (NTDs) with folate deficiency, we etablished mouse embryonic stem cells (mESCs) Sv/129 in folate-deficiency-treated.

2022-09-20 | GSE204869 | GEO

Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [RNA-seq]

Project description:To investigate the associated with the levels of DNA demethylation and neural tube defects (NTDs) with folate deficiency, we etablished mouse embryonic stem cells (mESCs) Sv/129 in folate-deficiency-treated. We then performed gene expression profiling analysis using data obtained from RNA-seq of the cell model.

2022-09-20 | GSE204871 | GEO

Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects

Project description:Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects

| PRJNA842651 | ENA

Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [MeDIP]

Project description:Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [MeDIP]

| PRJNA842657 | ENA

Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [RNA-seq]

Project description:Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [RNA-seq]

| PRJNA842658 | ENA

Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [ChIP-seq]

Project description:Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects [ChIP-seq]

| PRJNA842662 | ENA

Abnormal Transcriptome-wide of DNA demethylation in Folate deficiency caused neural tube defects

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-09-20 | GSE204874 | GEO

Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects

Project description:Neural tube defects (NTDs) are one of the most severe congenital abnormalities. Maternal folate deficiency could impact the occurrence of NTDs. Histone H3 methyltransferase disruptor of telomeric silencing 1-like (DOT1L) expression was significantly downregulated, and low levels of H3K79me2 were found in the corresponding NTDs samples with their maternal serum folate under low levels. Using ChIP-seq assays, we found that a decrease of H3K79me2 downregulates the expression of Shh and Sufu in mouse embryonic stem cells (mESC) under folate deficiency. Our results indicate that abnormal Shh and Sufu genes expression reduced by aberrant Dot1l-mediated H3K79me2 levels could be the cause of NTDs occurrence.

2023-07-25 | GSE238081 | GEO

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