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ATAC-seq analysis in Rpsa-iKO RAW264.7 cells after HSV-1 infection

ABSTRACT: ATAC-seq analysis in Rpsa-iKO RAW264.7 cells after HSV-1 infection

PROVIDER: PRJNA842689 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19416200_1.fastq.gz	Fastqsanger.gz
	SRR19416200_2.fastq.gz	Fastqsanger.gz
	SRR19416195_1.fastq.gz	Fastqsanger.gz
	SRR19416195_2.fastq.gz	Fastqsanger.gz
	SRR19416196_1.fastq.gz	Fastqsanger.gz

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ATAC-seq analysis in Rpsa-iKO RAW264.7 cells after HSV-1 infection

Project description:After HSV-1 infection, ribosomal protein RPSA can recognize viral DNA and promotes the expression of proinflammatory cytokines. Through ATAC-seq, we found that chromatin accessibility around transcription start sites (TSS) of proinflammatory cytokinse in HSV-1 infected Rpsa-iKO RAW264.7 was significantly reduced

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Project description:The purpose of this study was to determine which genes are differentially regulated virus infection in RAW264.7 cells. Cells were infected with Vesicular Stomatitis Virus (VSV) or herpes simplex virus 1 (HSV-1) for 6h. Then the differentially regulated genes were analyzed, focusing on F-box proteins and E3 ubiquitin ligases. RAW264.7 cells were infected with Vesicular Stomatitis Virus (VSV, MOI=1) or herpes simplex virus 1 (HSV-1, MOI=5) for 6h. Equal amounts of RNA were assayed for gene expression using Affymetrix mouse 430 2.0 arrays.

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