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Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells

ABSTRACT: Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells

PROVIDER: PRJNA843452 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19441259_1.fastq.gz	Fastqsanger.gz
	SRR19441259_2.fastq.gz	Fastqsanger.gz
	SRR19441260_1.fastq.gz	Fastqsanger.gz
	SRR19441260_2.fastq.gz	Fastqsanger.gz
	SRR19441261_1.fastq.gz	Fastqsanger.gz

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Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells

Project description:we investigated the effects of IH and epinephrine on gene expression in human aortic ECs using RNA-sequencing. We found a significant overlap between IH and epinephrine-induced differentially expressed genes (DEGs).

2022-09-05 | GSE205050 | GEO

Intermittent Hypoxia ageing

Project description:Intermittent Hypoxia ageing

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Intermittent Hypoxia ageing

Project description:Expression data from mice exposed to intermittent hypoxia and mice reared for 12 months. We used microarrays to analyze the transcriptome of hippocampus from mice exposed to intermittent hypoxia or aged mice.

2016-12-27 | GSE62385 | GEO

Effects of intermittent and chronic hypoxia on HAEC

Project description:Intermittent hypoxia (IH) in HeLa cell culture activates proinflammatory transcription factor NFκB, whereas chronic hypoxia (CH) does not. In order to determine whether IH may be linked to vascular inflammation, we developed a novel IH cell culture system and exposed HAEC (human aortic endothelial cells) to IH or CH. Keywords: Human Artery Endothelial Cells (HAEC)

2008-12-31 | GSE10723 | GEO

Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells.

Project description:Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular disease. While intermittent hypoxia (IH) and catecholamine release play an important role in this increased risk, the mechanisms are incompletely understood. We have recently reported that IH causes endothelial cell (EC) activation, an early phenomenon in the development of cardiovascular disease, via IH-induced catecholamine release. Here, we investigated the effects of IH and epinephrine on gene expression in human aortic ECs using RNA-sequencing. We found a significant overlap between IH and epinephrine-induced differentially expressed genes (DEGs) including enrichment in leukocyte migration, cytokine-cytokine receptor interaction, cell adhesion and angiogenesis. Epinephrine caused higher number of DEGs compared to IH. Interestingly, IH when combined with epinephrine had an inhibitory effect on epinephrine-induced gene expression. Combination of IH and epinephrine induced MT1G (Metallothionein 1G), which has been shown to be highly expressed in ECs from parts of aorta (i.e., aortic arch) where atherosclerosis is more likely to occur. In conclusion, epinephrine has a greater effect than IH on EC gene expression in terms of number of genes and their expression level. IH inhibited the epinephrine-induced transcriptional response. Further investigation of the interaction between IH and epinephrine is needed to better understand how OSA causes cardiovascular disease.

| S-EPMC9561121 | biostudies-literature

Intermittent and sustained hypoxia exposures activate distinct transcriptional responses in human aortic endothelial cells

Project description:Endothelial cell (EC) dysfunction precedes the development of cardiovascular disease in OSA; however, the mechanisms by which ECs respond to these hypoxic events is poorly understood. To better understand EC responses to hypoxia, we examined the effects of both sustained hypoxia (SH) and intermittent hypoxia (IH) on the activation of HIF-1α in Endothelial Cells (ECs). While SH stabilized HIF-1α and led to its nuclear localization, IH didn’t activate HIF-1α and its downsteram gene expression. Using RNA-sequencing, we evaluated transcriptional responses of ECs to hypoxia. SH induced expression of HIF-1α and hypoxia response genes, while IH affected cell-cycle regulation genes.

2024-11-01 | GSE279434 | GEO

GNPS_2018 Mouse intermittent hypoxia (IH) - Blood plasma

Project description:2018 Mouse intermittent hypoxia (IH) - Blood plasma Contains LC/MS data for 10-week experiments involving mice raised in environments with normal oxygen, intermittent hypoxia (IH) and intermittent hypercapnia (IC)

2019-02-25 | MSV000083482 | GNPS

Intermittent and sustained hypoxia exposures activate distinct transcriptional responses in human aortic endothelial cells

Project description:Intermittent and sustained hypoxia exposures activate distinct transcriptional responses in human aortic endothelial cells

| PRJNA1172698 | ENA

GNPS_2017 Mouse intermittent hypoxia (IH) - Blood plasma

Project description:2017 Mouse intermittent hypoxia (IH) - Blood plasma Contains LC/MS data for 10-week experiments involving mice raised in environments with normal oxygen, intermittent hypoxia (IH).

2019-02-25 | MSV000083481 | GNPS

GNPS_2017 Mouse intermittent hypoxia (IH) - Aorta & pulmonary artery

Project description:2017 Mouse intermittent hypoxia (IH) - Aorta & pulmonary artery Contains LC/MS data for 10-week experiments involving mice raised in environments with normal oxygen, intermittent hypoxia (IH).

2019-02-25 | MSV000083483 | GNPS

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