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Effect of depletion of Nucleoporin Seh1 on gene expression during proliferation and differentiation of neural stem cell

ABSTRACT: Effect of depletion of Nucleoporin Seh1 on gene expression during proliferation and differentiation of neural stem cell

PROVIDER: PRJNA843734 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19447992.fastq.gz	Fastqsanger.gz
	SRR19447994.fastq.gz	Fastqsanger.gz

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Effect of depletion of Nucleoporin Seh1 on gene expression during proliferation and differentiation of neural stem cell

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Project description:Nuclear pore complex components (Nups) are involved in neural development and alterations in Nup genes are linked to human neurological diseases. However, the physiological functions of specific Nups and the underlying mechanisms involved in these processes remain elusive. Here we show that tissue-specific depletion of nucleoporin Seh1 causes dramatic myelination defects in the Central Nervous System (CNS). Seh1-deficient Oligodendrocyte Progenitor Cells (OPCs) proliferate properly, but fail to differentiate into mature oligodendrocytes, which impairs myelin production and remyelination after demyelinating injury. Genome-wide analyses show that Seh1 regulates a core myelinogenic regulatory network and depletion of Seh1 alters open chromatin configurations at its target genes. Mechanistically, Seh1 regulates OPCs differentiation by assembling Olig2 and Brd7 into a transcription complex at nuclear pores. Together, our results reveal that Seh1 is required for oligodendrocyte differentiation and myelination by promoting assembly of an Olig2-dependent transcription complex and expose nucleoporins as key players in the CNS.

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