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Modulation of behavioral and hippocampal transcriptomic responses in rat prolonged chronic unpredictable stress model by fluoxetine, eicosapentaenoic acid and lipopolysaccharide

ABSTRACT: Modulation of behavioral and hippocampal transcriptomic responses in rat prolonged chronic unpredictable stress model by fluoxetine, eicosapentaenoic acid and lipopolysaccharide

PROVIDER: PRJNA844390 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19510949_1.fastq.gz	Fastqsanger.gz
	SRR19510949_2.fastq.gz	Fastqsanger.gz
	SRR19510950_1.fastq.gz	Fastqsanger.gz
	SRR19510950_2.fastq.gz	Fastqsanger.gz
	SRR19510951_1.fastq.gz	Fastqsanger.gz

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Modulation of behavioral and hippocampal transcriptomic responses in rat prolonged chronic unpredictable stress model by fluoxetine, eicosapentaenoic acid and lipopolysaccharide

Project description:Here, we examine behavioral and brain transcriptomic (RNA-seq) responses in rat prolonged chronic unpredictable stress (PCUS) model, and their modulation by 4-week treatment with fluoxetine, eicosapentaenoic acid (EPA), lipopolysaccharide (LPS) and their combinations.

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Modulation of behavioral and neurochemical responses of adult zebrafish by fluoxetine, eicosapentaenoic acid and lipopolysaccharide in the prolonged chronic unpredictable stress model.

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Project description:This study aims at investigating the role of IL-17 in fluoxetine resistance in depression.The WGCNA analysis was utilized to analyze differentially expressed genes between response to antidepressant (GRA) group and resistance to antidepressant (AR)group. Furthermore, the treatment resistance model of depression was established inChronic unpredictable mild stress (CUMS) mice administrated with fluoxetine (widely used clinical medication for the treatment of depression) according to sucrose preference rate. Depression-like behaviors in mice were detected in Control group, CUMS group, GRA group, AR group, SR1001 (Th17 differentiation inhibitor) group. Subsequently, HT22 cells were exposed to IL-17 secreted by Th17 differentiation. Transcriptome sequencing from the Control and IL-17 group was used to screen differential genes. And then HT22 cells were transfected with si-JAK1 or si-STAT6. Th17 differentiation, the integrity of the blood-brain barrier (BBB), JAK1-STAT6 signaling pathway related proteins were detected by western blot, immunocytochemistry, flow cytometric analysis, ELISA experiments, immunofluorescence, and PCR. The inhibition of Th17 differentiation and the reduction of peripheral IL-17 release could increase their sensitivity to fluoxetine resistance and relieve the depression-like behavior. This process may be associated with the JAK1-STAT6 pathway.

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