Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Exploring the Genomic Dark Matter of Neurodevelopmental Disorders

ABSTRACT: Exploring the Genomic Dark Matter of Neurodevelopmental Disorders

PROVIDER: PRJNA844471 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Exploring the Genomic Dark Matter of Neurodevelopmental Disorders

Project description:Exploring the Genomic Dark Matter of Neurodevelopmental Disorders

| PRJNA844470 | ENA

Extensive binding of uncharacterized human transcription factors to genomic dark matter [NewChIP_ERP163147]

Project description:Most of the human genome is thought to be non-functional, and includes large segments often referred to as “dark matter” DNA. The genome also encodes hundreds of putative and poorly characterized transcription factors (TFs). We determined genomic binding locations of 166 uncharacterized human TFs in living cells. Nearly half of them associated strongly with known regulatory regions such as promoters and enhancers, often at conserved motif matches and co-localizing with each other. Surprisingly, the other half often associated with genomic dark matter, at largely unique sites, via intrinsic sequence recognition. Dozens of these, which we term “Dark TFs” mainly bind within regions of closed chromatin. Dark TF binding sites are rarely under purifying selection, and are enriched for transposable elements. Many Dark TFs are KZNFs, which contain the repressive KRAB domain, but many are not, and may represent potential pioneer TFs: based on compiled literature information, the Dark TFs exert diverse functions ranging from early development to tumor suppression. Thus, a large fraction of previously uncharacterized human TFs may have unappreciated activities within the dark matter genome.

2024-11-11 | GSE280165 | GEO

Gene dosage imbalance in neurodevelopmental disorders

Project description:Gene dosage imbalance in neurodevelopmental disorders

| PRJNA287736 | ENA

Extensive binding of uncharacterized human transcription factors to genomic dark matter [GSE58341 Reanalysis]

2024-11-11 | GSE280247 | GEO

Extensive binding of uncharacterized human transcription factors to genomic dark matter [GSE76494 Reanalysis]

2024-11-11 | GSE280246 | GEO

Smooth Mat Microbial Dark Matter

Project description:Novel microbial dark matter shaping Shark Bay microbialites

| PRJNA561032 | ENA

GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders Mice

Project description:Mice experiment for GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders

2024-03-28 | E-MTAB-13475 | biostudies-arrayexpress

GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders Organoid

Project description:Mice experiment for GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders

2024-04-15 | E-MTAB-13477 | biostudies-arrayexpress

Presynaptic dysfunction in CASK-related neurodevelopmental disorders

Project description:Presynaptic dysfunction in CASK-related neurodevelopmental disorders

| PRJNA590196 | ENA

GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders Organoid SC

Project description:GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders Organoid SC

2024-06-27 | E-MTAB-13478 | biostudies-arrayexpress