Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: IMP-type metallo-beta-lactamase Supplement

PROVIDER: PRJNA844926 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19524222_1.fastq.gz	Fastqsanger.gz
	SRR19524222_2.fastq.gz	Fastqsanger.gz
	SRR19524223_1.fastq.gz	Fastqsanger.gz
	SRR19524223_2.fastq.gz	Fastqsanger.gz
	SRR19524224_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Klebsiella pneumoniae strain:TA6363

Project description:IMP-type Metallo-beta-lactamase-producing Klebsiella pneumoniae WGS

| PRJDB8047 | ENA

Enterobacteriaceae

Project description:A transferrable IncL/M plasmid harboring IMP-1 metallo-beta-lactamase

| PRJDB11945 | ENA

Cefazolin and Imipenem Enhance AmpC Expression and Resistance in NagZ-dependent manner in Enterobacter cloacae complex

Project description:Background: Enterobacter cloacae complex (ECC) is a common opportunistic pathogen and is responsible for causing various infections in humans. Owing to its inducible chromosomal AmpC β-lactamase (AmpC), ECC is inherently resistant to the 1st- and 2nd- generation cephalosporins. However, whether β-lactams antibiotics enhance ECC resistance remains unclear. Results: In this study, we found that subinhibitory concentrations (SICs) of cefazolin (CFZ) and imipenem (IMP) can advance the expression of AmpC and enhance its resistance towards β-lactams through NagZ in Enterobacter cloacae (EC). Further, AmpC manifested a substantial upregulation in EC in response to SICs of CFZ and IMP. In nagZ knockout EC (ΔnagZ), the resistance to β-lactam antibiotics was rather weakened and the effect of CFZ and IMP on AmpC induction was completely abrogated. NagZ ectopic expression can rescue the induction effects of CFZ and IMP on AmpC and increase ΔnagZ resistance. More importantly, CFZ and IMP have the potential to induce the expression of AmpR's target genes in a NagZ-dependent manner. Conclusions: Our findings suggest that NagZ is a critical determinant for CFZ and IMP to promote AmpC expression and resistance and that CFZ and IMP should be used with caution since they may aggravate ECC resistance. At the same time, this study further improves our understanding of resistance mechanisms in ECC.

2022-07-01 | GSE207144 | GEO

Project description:Metallo-beta-lactamase NDM-1 encoding strains

| PRJNA260717 | ENA

Project description:Metallo-beta-lactamase-producing Pseudomonas aeruginosa in Switzerland

| PRJNA1044010 | ENA

Escherichia coli

Project description:Escherichia coli producing New Delhi metallo-beta-lactamase (NDM)

| PRJNA399755 | ENA

Project description:Deep mutational scanning of NDM-1 metallo-beta-lactamase

| PRJNA974578 | ENA

Alcaligenes faecalis

Project description:A novel new metallo-beta-lactamase gene: NDM-likelihood gene.

| PRJNA497246 | ENA

Pseudomonas spp.

Project description:Metallo-beta-lactamase-encoding plasmids from Pseudomonas spp. clinical isolates

| PRJNA527981 | ENA

Pseudomonas aeruginosa

Project description:Difficult-to-Treat Pseudomonas Harboring Verona-Integron Metallo-beta-lactamase

| PRJNA1064149 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data