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TRIM28 modulates progesterone and estrogen signaling in endometrium

ABSTRACT: TRIM28 modulates progesterone and estrogen signaling in endometrium

PROVIDER: PRJNA845794 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19542908.fastq.gz	Fastqsanger.gz
	SRR19542909.fastq.gz	Fastqsanger.gz
	SRR19540612_1.fastq.gz	Fastqsanger.gz
	SRR19540612_2.fastq.gz	Fastqsanger.gz
	SRR19540613_1.fastq.gz	Fastqsanger.gz

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TRIM28 modulates progesterone and estrogen signaling in endometrium [mouseD35-PGR-ChIPseq-mm10]

Project description:TRIM28 modulates progesterone and estrogen signaling in endometrium [mouseD35-PGR-ChIPseq-mm10]

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TRIM28 modulates progesterone and estrogen signaling in endometrium [mouseD35-PGR-ChIPseq-mm10]

Project description:TRIM28 interacts with PGR and ESR1 in both human and mouse uterus to modulate estrogen and progesterone signaling. Knocking down of TRIM28 in the human endometrial stromal cells impaired decidualization in vitro. Deletion of TRIM28 from mouse uterus disrupted uterine stromal decidualization leading to infertility. Additionally, TRIM28 deletion caused abnormal accumulation of TRIM28 positive and PGR negative cells in the stroma.

2023-06-04 | GSE226623 | GEO

TRIM28 modulates progesterone and estrogne signaling in endometrium [ATACseq-hg38]

Project description:TRIM28 interacts with PGR and ESR1 in both human and mouse uterus to modulate estrogen and progesterone signaling. Knocking down of TRIM28 in the human endometrial stromal cells imparied decidualization in vitro. Deletion of TRIM28 from mouse uterus disrupted uterine stromal decidualization leading to infertility. Addtionally, TRIM28 deletion caused abnormal accumulation of TRIM28 postive and PGR negative cells in the stroma.

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TRIM28 modulates nuclear receptor signaling to regulate uterine function

Project description:This project identified that TRIM28 can modulate progesterone and estrogen signaling in both human and mouse endometrium to regulate its normal functions during pregnancy. TRIM28 showed proximal localization and co-immunoprecipitation with PR and ERalpha. The ablation of TRIM28 can inhibit the chromatin binding activity of PR and ERalpha leading to disrupted estrogen and progesterone signaling. This immunoprecipitation using TRIM28 antibody was performed in pre-decidual human endometrial stromal cells (HESCs) without any hormone treatment. The potential interacting proteins of TRIM28 was analyzed using mass spec.

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TRIM28 modulates progesterone and estrogne signaling in endometrium [ATACseq-hg38]

Project description:TRIM28 modulates progesterone and estrogne signaling in endometrium [ATACseq-hg38]

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TRIM28 modulates progesterone and estrogne signaling in endometrium [mouse-D3.5-scRNAseq]

Project description:TRIM28 interacts with PGR and ESR1 in both human and mouse uterus to modulate estrogen and progesterone signaling. Knocking down of TRIM28 in the human endometrial stromal cells imparied decidualization in vitro. Deletion of TRIM28 from mouse uterus disrupted uterine stromal decidualization leading to infertility. Addtionally, TRIM28 deletion caused abnormal accumulation of TRIM28 postive and PGR negative cells in the stroma.

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TRIM28 modulates progesterone and estrogne signaling in endometrium [HESC-RNAseq-hg19]

Project description:TRIM28 interacts with PGR and ESR1 in both human and mouse uterus to modulate estrogen and progesterone signaling. Knocking down of TRIM28 in the human endometrial stromal cells imparied decidualization in vitro. Deletion of TRIM28 from mouse uterus disrupted uterine stromal decidualization leading to infertility. Addtionally, TRIM28 deletion caused abnormal accumulation of TRIM28 postive and PGR negative cells in the stroma.

2023-06-04 | GSE205477 | GEO

TRIM28 modulates progesterone and estrogne signaling in endometrium [mouseD35-ChIPseq-mm10]

Project description:TRIM28 interacts with PGR and ESR1 in both human and mouse uterus to modulate estrogen and progesterone signaling. Knocking down of TRIM28 in the human endometrial stromal cells imparied decidualization in vitro. Deletion of TRIM28 from mouse uterus disrupted uterine stromal decidualization leading to infertility. Addtionally, TRIM28 deletion caused abnormal accumulation of TRIM28 postive and PGR negative cells in the stroma.

2023-06-04 | GSE205476 | GEO

TRIM28 modulates progesterone and estrogne signaling in endometrium [HESC-ChIPseq-hg38]

Project description:TRIM28 interacts with PGR and ESR1 in both human and mouse uterus to modulate estrogen and progesterone signaling. Knocking down of TRIM28 in the human endometrial stromal cells imparied decidualization in vitro. Deletion of TRIM28 from mouse uterus disrupted uterine stromal decidualization leading to infertility. Addtionally, TRIM28 deletion caused abnormal accumulation of TRIM28 postive and PGR negative cells in the stroma.

2023-06-04 | GSE205475 | GEO

TRIM28 modulates progesterone and estrogne signaling in endometrium [mouseP4-RNAseq-mm10]

Project description:TRIM28 interacts with PGR and ESR1 in both human and mouse uterus to modulate estrogen and progesterone signaling. Knocking down of TRIM28 in the human endometrial stromal cells imparied decidualization in vitro. Deletion of TRIM28 from mouse uterus disrupted uterine stromal decidualization leading to infertility. Addtionally, TRIM28 deletion caused abnormal accumulation of TRIM28 postive and PGR negative cells in the stroma.

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