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Zika virus co-opts miRNA networks to persist in placental microenvironments detected by spatial transcriptomics [AGO-HITS-CLIP]

ABSTRACT: Zika virus co-opts miRNA networks to persist in placental microenvironments detected by spatial transcriptomics [AGO-HITS-CLIP]

PROVIDER: PRJNA846714 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19572733.fastq.gz	Fastqsanger.gz
	SRR19572734.fastq.gz	Fastqsanger.gz
	SRR19572735.fastq.gz	Fastqsanger.gz
	SRR19572736.fastq.gz	Fastqsanger.gz
	SRR19572737.fastq.gz	Fastqsanger.gz

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Similar Datasets

Zika virus co-opts miRNA networks to persist in placental microenvironments detected by spatial transcriptomics [AGO-HITS-CLIP]

Project description:We and others have demonstrated Zika virus (ZIKV) congenital infection evades double-stranded RNA detection, and may persist in the placenta for the duration of pregnancy without accompanying overt histopathologic inflammation. We used orthogonal approaches to test the hypothesis that ZIKV disrupts placental miRNAs to enable viral persistence and fetal pathogenesis. In primary human trophoblasts, high-throughput sequencing crosslinking and immunoprecipitation (AGO-HITS-CLIP) demonstrated an unexpected disruption of placental miRNA-regulated TGF-β networks. In gnotobiotic mice, absence of microbes rendered normally resistant mice susceptible to congenital ZIKV infection, and placental spatial transcriptomics revealed distinct microenvironments defined by significant upregulation of complement cascade components. Finally, treatment of ZIKV-infected mice with the RNAi-enhancer enoxacin led to loss of ZIKV placental persistence and rescue of fetal growth restriction. These results collectively suggest that ZIKV co-opts miRNA inflammatory regulatory networks to persist in the placenta reservoir, a conduit of vertical transmission and fetal pathogenesis.

2023-06-03 | GSE205609 | GEO

Zika virus co-opts miRNA networks to persist in placental microenvironments detected by spatial transcriptomics [visium]

2023-06-03 | GSE205631 | GEO

Zika virus co-opts miRNA networks to persist in placental microenvironments detected by spatial transcriptomics

Project description:Zika virus co-opts miRNA networks to persist in placental microenvironments detected by spatial transcriptomics

| PRJNA846741 | ENA

Zika virus co-opts miRNA networks to persist in placental microenvironments detected by spatial transcriptomics [visium]

Project description:Zika virus co-opts miRNA networks to persist in placental microenvironments detected by spatial transcriptomics [visium]

| PRJNA846745 | ENA

Zika virus co-opts miRNA networks to persist in placental microenvironments detected by spatial transcriptomics

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-06-03 | GSE205632 | GEO

Camk2a-neuron specific FLAG-Ago HITS-CLIP

Project description:The HITS-CLIP procedure was used to detect miRNA mediated Argonaute (Ago) binding in Camk2a mouse neurons.

2023-01-31 | GSE211552 | GEO

Camk2a-neuron specific FLAG-Ago HITS-CLIP

Project description:Camk2a-neuron specific FLAG-Ago HITS-CLIP

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AGO pathway

Project description:AGO pathway

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AGO HITS-CLIP Reveals Distinct Patterns of miRNA Regulation of Visceral and Brown Adipose Tissue Identity

Project description:Wildtype mouse adipose tissue was dissected and subjected to Ago-CLIP sequencing to identify Ago:RNA regulatory sites and RNA sequencing. Adipose tissue from a separate cohort of mice was used for small RNA sequencing.

2019-12-28 | GSE142677 | GEO

Ago HITS-CLIP in KSHV-infected primary effusion lymphoma (PEL) cell lines BCBL-1 and BC-3

Project description:We performed Ago HITS-CLIP to identify targets of viral and human miRNAs in latently KSHV-infected PEL cells Ago HITS-CLIP was performed in two latently infected PEL cell lines, BCBL-1 and BC-3; Argonaute-immunoprecipitation of UV cross-linked Ago-miRNA-mRNA complexes, followed by RNA isolation, library construction, and high-throughput sequencing (Illumina GAxII); we performed 3 biological replicates for each cell line, two technical (sequencing) replicates of BCBL-1 biological replicate 1

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