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Effect of depletion of GMDS-AS1 on gene expression of HCT116 colorectel cancer cells

ABSTRACT: Effect of depletion of GMDS-AS1 on gene expression of HCT116 colorectel cancer cells

PROVIDER: PRJNA846740 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19573458_1.fastq.gz	Fastqsanger.gz
	SRR19573458_2.fastq.gz	Fastqsanger.gz
	SRR19573459_1.fastq.gz	Fastqsanger.gz
	SRR19573459_2.fastq.gz	Fastqsanger.gz
	SRR19573460_1.fastq.gz	Fastqsanger.gz

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Effect of depletion of GMDS-AS1 on gene expression of HCT116 colorectel cancer cells

Project description:To detect the biological function of LncRNA GMDS-AS1 in colorectal cancer tumorigenesis, we constructed lentivirus-infected stable GMDS-AS1-knockdown (KD) HCT116 cell lines using shRNA (GMDS-AS1 shRNA2) and a nontarget control shRNA Next we performed gene expression profiling analysis using data obtained from RNA-seq of control and GMDS-AS1 KD cells, three biological replicates were applied.

2022-06-10 | GSE205630 | GEO

Effect of depletion of MIB1 in HCT116 cells

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Effect of depletion of C15ORF48/miR-147 on gene expression in primary colonocytes [HCT116]

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Effects of SOCS2-AS1 inhibition in prostate cancer cells

Project description:Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation. We identified a novel androgen-regulated long non-coding (lnc) RNA, SOCS2-AS1. In order to investigate the SOCS2-AS1 function in prostate cancer cells, we performed gene expression in AR-positive prostate cancer cell lines (LNCaP and LTAD) after siSOCS2-AS1 or siSOCS2 treatment. We also treated cells with vehicle or androgen to analyzed the effects of siSOCS2-AS1 on AR function. Observation of androgen dependent gene expression changes after treatmet with siSOCS2-AS1 with microarray.

2016-08-01 | E-GEOD-82224 | biostudies-arrayexpress

Effect of depletion of MIB1 in HCT116 cells

Project description:To investigate gene regulation by MIB1 in HCT116 cells, we established stable knockdown HCT116 cell lines.

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Knockdown of lncRNA NR2F1-AS1 in gastric cancer cells

Project description:Our data showed that NR2F1-AS1 functions oncogenic roles in gastric cancer (GC), but the underlying molecular mechanism remains largely unknown to date. To explore the function of lncRNA NR2F1-AS1 in gastric cancer, loss-of-function and RNA sequencing studies were performed in SGC7901 cell line. The results showed that depletion of NR2F1-AS1 significantly decreased the expression of VAMP7. Interestingly, VAMP7 was also a target gene of miR-29a-3p. Our data showed that NR2F1-AS1 promotes GC progression through regulating miR-29a/VAMP7 axis.

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Effects of DAB2IP depletion on gene expression in HCT116 cells

Project description:Effects of DAB2IP depletion on gene expression in HCT116 cells

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RNA-seq of depletion Mina53 in HCT116 p53+/+ cells and HCT116 p53-/- cells

Project description:RNA-seq of depletion Mina53 in HCT116 p53+/+ cells and HCT116 p53-/- cells

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MNX1-AS1, a c-Myc induced lncRNA, promotes the Warburg effect by regulating PKM2 nuclear translocation

Project description:Altered glycolysis is the most fundamental metabolic change associated with the Warburg effect. However, the precise mechanisms are not completely understood. Here we dissect how MNX1-AS1 reinforces the Warburg effect through facilitating the non-glycolytic actions of PKM2 in the nucleus. We found that MNX1-AS1 expression was frequently overexpressed in hepatocellular carcinoma (HCC). In the context of HCC, we show MNX1-AS1 acts as a scaffold to promote interactions between PKM2 and importin α5. Upon EGFR activation, the resulting ternary complex drives the translocation of PKM2 into the nucleus. In consequence, glycolytic pathway components including key mediators of the Warburg effect (LDHA, Glut1 and PDK1) are upregulated. Manipulating MNX1-AS1 elicited robust effects on glycolysis associated with marked changes in HCC growth in vitro and in vivo, indicative of the significant contribution of MNX1-AS1 to tumorigenesis. Moreover, while MNX1-AS1 expression is driven by c-Myc, its actions associated with PKM2 were shown to be downstream and independent of c-Myc. Given the status of MNX1-AS1 as a pan-cancer upregulated lncRNA, this implicitly highlights the potential of targeting MNX1-AS1 to selectively counter the Warburg effect in a range of tumor types.

2022-11-23 | GSE213064 | GEO

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