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A discrete 'early-responder' stromal-cell subtype orchestrates immunocyte recruitment to injured tissue, thereby promoting regeneration [scRNA-seq]

ABSTRACT: A discrete 'early-responder' stromal-cell subtype orchestrates immunocyte recruitment to injured tissue, thereby promoting regeneration [scRNA-seq]

PROVIDER: PRJNA847324 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19591782_1.fastq.gz	Fastqsanger.gz
	SRR19591782_2.fastq.gz	Fastqsanger.gz
	SRR19591783_1.fastq.gz	Fastqsanger.gz
	SRR19591783_2.fastq.gz	Fastqsanger.gz
	SRR19591784_1.fastq.gz	Fastqsanger.gz

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A discrete 'early-responder' stromal-cell subtype orchestrates immunocyte recruitment to injured tissue, thereby promoting regeneration.

Project description:A discrete 'early-responder' stromal-cell subtype orchestrates immunocyte recruitment to injured tissue, thereby promoting regeneration.

| PRJNA847322 | ENA

A discrete 'early-responder' stromal-cell subtype orchestrates immunocyte recruitment to injured tissue, thereby promoting regeneration [RNA-seq]

Project description:A discrete 'early-responder' stromal-cell subtype orchestrates immunocyte recruitment to injured tissue, thereby promoting regeneration [RNA-seq]

| PRJNA847184 | ENA

A discrete 'early-responder' stromal-cell subtype orchestrates immunocyte recruitment to injured tissue, thereby promoting regeneration [scRNA-seq]

Project description:Following acute injury, stromal cells promote tissue regeneration by diverse mechanisms. Time-resolved single-cell RNA sequencing of muscle mesenchymal stromal cells (MmSCs) responding to cardiotoxin(CTX)-induced injury identified an “early-responder” subtype that spiked on day 1 and expressed a striking array of transcripts encoding immunomodulators. IL-1b, TNFa and oncostatin M, primarily produced by myeloid cells, each strongly and rapidly induced MmSCs transcribing most of these immunomodulators. Transfer of the inflammatory MmSC subtype, tagged with a unique surface marker, into healthy hindlimb muscle induced inflammation primarily driven by neutrophils and macrophages. Among the abundant inflammatory transcripts produced by this subtype, Cxcl5 was stroma-specific and highly upregulated with injury. Depletion of this chemokine early after injury revealed a non-redundant impact on recruitment of neutrophils, a prolongation of inflammation at later times, and ineffectual tissue regeneration. MmSC subtypes expressing a comparable inflammatory program were found in a mouse model of muscular dystrophy and in several other tissues and pathologies in both mice and humans. These “early-responder” MmSCs, already in place, permit rapid and coordinated mobilization and amplification of critical cell collaborators during tissue regeneration.

2022-12-31 | GSE205737 | GEO

A discrete 'early-responder' stromal-cell subtype orchestrates immunocyte recruitment to injured tissue, thereby promoting regeneration [RNA-seq]

Project description:Following acute injury, stromal cells promote tissue regeneration by diverse mechanisms. Time-resolved single-cell RNA sequencing of muscle mesenchymal stromal cells (MmSCs) responding to cardiotoxin (CTX)-induced injury identified an “early-responder” subtype that spiked on day 1 and expressed a striking array of transcripts encoding immunomodulators. IL-1b, TNFa and oncostatin M, primarily produced by myeloid cells, each strongly and rapidly induced MmSCs transcribing most of these immunomodulators. Transfer of the inflammatory MmSC subtype, tagged with a unique surface marker, into healthy hindlimb muscle induced inflammation primarily driven by neutrophils and macrophages. Among the abundant inflammatory transcripts produced by this subtype, Cxcl5 was stroma-specific and highly upregulated with injury. Depletion of this chemokine early after injury revealed a non-redundant impact on recruitment of neutrophils, a prolongation of inflammation at later times, and ineffectual tissue regeneration. MmSC subtypes expressing a comparable inflammatory program were found in a mouse model of muscular dystrophy and in several other tissues and pathologies in both mice and humans. These “early-responder” MmSCs, already in place, permit rapid and coordinated mobilization and amplification of critical cell collaborators during tissue regeneration.

2022-12-31 | GSE205688 | GEO

A discrete 'early-responder' stromal-cell subtype orchestrates immunocyte recruitment to injured tissue, thereby promoting regeneration.

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-12-31 | GSE205738 | GEO

mRNA profiles from dorsal raphe and amygdala of high-responder and low-responder rats

Project description:We identified 271 transcripts as differentially regulated in the dorsal raphe and/or the amygdala of high-responder and low-responder rats

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Interleukin-17 governs hypoxic adaptation of injured epithelium [CITE-seq & single-cell RNA-seq]

Project description:To define the composition of “first responder” lymphocytes that may engage in crosstalk with injured epithelium we profiled the lymphoytes from unwounded health skin and skin from different time points after wounding with CITE-seq and single-cell RNA-sequencing.

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Responder and non-responder proteomic and phosphoproteomic profiles to ATRA/Valproic acid before treatment

Project description:Proteomic and phosphoproteomic raw files from responder and non-responder acute myeloid leukemia patient samples before initiation of ATRA/valproic acid treatment

2021-09-10 | PXD024110 | Pride

microRNA profiles from dorsal raphe and amygdala of high-responder and low-responder rats

Project description:We report 33 microRNAs are differentially expressed in the dorsal raphe and/or amygdala of rats selectively bred for high and low locomotor response to novelty (high responder and low responder rats)

2017-03-12 | GSE86934 | GEO

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2023-12-14 | MSV000093670 | MassIVE

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