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Parenchymal border macrophages regulate CSF flow dynamics [5xFAD]

ABSTRACT: Parenchymal border macrophages regulate CSF flow dynamics [5xFAD]

PROVIDER: PRJNA849229 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19656606_1.fastq.gz	Fastqsanger.gz
	SRR19656606_2.fastq.gz	Fastqsanger.gz
	SRR19656607_1.fastq.gz	Fastqsanger.gz
	SRR19656607_2.fastq.gz	Fastqsanger.gz
	SRR19656608_1.fastq.gz	Fastqsanger.gz

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Parenchymal border macrophages regulate CSF flow dynamics

Project description:Parenchymal border macrophages regulate CSF flow dynamics

| PRJNA778201 | ENA

Parenchymal border macrophages regulate CSF flow dynamics [brain]

Project description:Parenchymal border macrophages regulate CSF flow dynamics [brain]

| PRJNA778204 | ENA

Parenchymal border macrophages regulate CSF flow dynamics [5xFAD]

Project description:Microglial cells are the resident macrophages of the brain. Perivascular macrophages (PVM) are also myeloid resident cells that are located at the interface between blood, CSF and brain in the perivascular space. Due to their strategic location and their ability to sample CSF content, we hypothesized that PVM might play a role in CSF flow. Using different fluorescent tracers injected either into the CSF (influx) or the brain parenchyma (efflux) we assessed their spatio-temporal distribution and found that ablation (using clodronate liposomes) or dysfunction (using genetic tools) of PVM alters CSF dynamics and patterns. Using single cell RNA sequencing, we found that PBMs can be divided in two sub-populations, and that one population of PBMs could interact with vascular smooth muscle cells, which allow arterial pulsations and subsequently CSF flow. Interestingly, aging results in altered PVM phenotype, and reversing this phenotype using macrophage specific grown factors reversed some of aging-associated dysfunctions of CSF flow. In summary, our results identify a new role of PVM in CSF flow and open new avenues for therapeutical applications targeting PVM in neurodegenerative diseases such as Alzheimer’s disease.

2022-08-31 | GSE206114 | GEO

Parenchymal border macrophages regulate CSF flow dynamics [leptomeningeal macs]

Project description:Parenchymal border macrophages regulate CSF flow dynamics [leptomeningeal macs]

| PRJNA778203 | ENA

Parenchymal border macrophages regulate CSF flow dynamics [CLO depletion]

Project description:Parenchymal border macrophages regulate CSF flow dynamics [CLO depletion]

| PRJNA849230 | ENA

Parenchymal border macrophages regulate CSF flow dynamics [brain]

2022-08-31 | GSE188283 | GEO

Parenchymal border macrophages regulate CSF flow dynamics [leptomeningeal macs]

2022-08-31 | GSE188284 | GEO

Parenchymal border macrophages regulate CSF flow dynamics [CLO depletion]

2022-08-31 | GSE206115 | GEO

Parenchymal border macrophages regulate CSF flow dynamics

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-31 | GSE188285 | GEO

Limited effects of an eIF2αS51A allele on neurological impairments in the 5xFAD mouse model of Alzheimer’s disease

Project description:Transcriptome analysis of hippocampal RNA samples from wild-type, 5xFAD, 5xFAD;eIF2α+/S51A and eIF2α+/S51A mice Our transcriptome analyses showed clear transcriptional alterations in hippocampi of 5xFAD compared to wild type mice that were not corrected by the eIF2αS51A allele. Hemizygous 5xFAD mice, which were on a genetic background of B6/SJL, were crossed with eIF2α+/S51A mice (C57BL/6J background), to generate the offspring that was analyzed in the microarray. Hippocampal samples of 12 mice (4 groups: wild-type, 5xFAD, 5xFAD;eIF2α+/S51A and eIF2α+/S51A) were processed using Affymetrix Mouse Exon 1.0 ST platform. Array data was processed by Affymetrix Exon Array Computational Tool. No technical replicates were performed.

2013-09-10 | E-GEOD-50521 | biostudies-arrayexpress

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