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Transcriptomic clustering of critically-ill COVID-19 patients [Day 4 RNAseq]

ABSTRACT: Transcriptomic clustering of critically-ill COVID-19 patients [Day 4 RNAseq]

PROVIDER: PRJNA849923 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19682760.fastq.gz	Fastqsanger.gz
	SRR19682761.fastq.gz	Fastqsanger.gz
	SRR19682762.fastq.gz	Fastqsanger.gz
	SRR19682763.fastq.gz	Fastqsanger.gz
	SRR19682764.fastq.gz	Fastqsanger.gz

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Transcriptomic clustering of critically-ill COVID-19 patients

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Transcriptomic clustering of critically-ill COVID-19 patients

Project description:This SuperSeries is composed of the SubSeries listed below.

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People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burden

Project description:There remains an urgent need to delinate immune cell states that contribute to mortality in critially ill COVID-19 patients. To better understand determinants of mortality, we performed high dimensional profiling of blood and respiratory samples from critially ill COVID-19 patients. Single-cell RNAseq based characterization of peripheral immune states reveal distinct expression profiles that were predictive of COVID-19 mortality. Temporal analysis revealed a that persistently elevated levels of inflammatory monocyte signatures and persistent interferon signaling preceeded concerted upregulation of inflammatory cytokines. Interrogation of lower respiratory tract saples revelaed that infected myeliod cells upregulated CXCL10, and elevated levels of CXCL10 in plasma were associated with a high risk of death. Overall, our data suggest a pivotal role for myeloid cell states in severe COVID-19 and may faciliate discovery of new diagnostics and therapeutics.

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