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Hepatocyte SREBP signaling mediates clock communication within the liver [RNA-seq]

ABSTRACT: Hepatocyte SREBP signaling mediates clock communication within the liver [RNA-seq]

PROVIDER: PRJNA850018 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19702009_1.fastq.gz	Fastqsanger.gz
	SRR19702009_2.fastq.gz	Fastqsanger.gz
	SRR19702010_1.fastq.gz	Fastqsanger.gz
	SRR19702010_2.fastq.gz	Fastqsanger.gz
	SRR19702011_1.fastq.gz	Fastqsanger.gz

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Hepatocyte SREBP signaling mediates clock communication within the liver

Project description:Hepatocyte SREBP signaling mediates clock communication within the liver

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Hepatocyte SREBP signaling mediates clock communication within the liver [ATAC-seq]

Project description:Rhythmic intraorgan communication coordinates environmental signals and cell-intrinsic clock to maintain organ homeostasis. Hepatocyte-specific knockout of core components of the molecular clock, Rev-erba and b (ReverbhDKO), alters cholesterol and lipid metabolism in hepatocytes as well as rhythmic gene expression in non-parenchymal cells (NPC) of the liver. Here we report that in diet induced obesity (DIO)-caused fatty liver, hepatocyte SREBP cleavage-activating protein (SCAP) is required for ReverbhDKO-induced diurnal rhythmic remodeling and epigenomic reprogramming in Kupffer cells (KC). Integrative analyses of isolated hepatocytes and Kupffer cells uncovered potential signals, including secreted polypeptides and metabolites, that gain rhythmicity in the absence of REV-ERBs in a SCAP-dependent manner. These results shed light on the signaling mechanisms by which hepatocytes regulate diurnal rhythms in NPCs in DIO and fatty liver disease.

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Hepatocyte SREBP signaling mediates clock communication within the liver [scRNA-seq]

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Hepatocyte SREBP signaling mediates clock communication within the liver [RNA-seq]

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Hepatocyte SREBP signaling mediates clock communication within the liver [ATAC-seq]

Project description:Hepatocyte SREBP signaling mediates clock communication within the liver [ATAC-seq]

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Hepatocyte SREBP signaling mediates clock communication within the liver [scRNA-seq]

Project description:Hepatocyte SREBP signaling mediates clock communication within the liver [scRNA-seq]

| PRJNA850017 | ENA

Hepatocyte SREBP signaling mediates clock communication within the liver.

Project description:Rhythmic intraorgan communication coordinates environmental signals and the cell-intrinsic clock to maintain organ homeostasis. Hepatocyte-specific KO of core components of the molecular clock Rev-erbα and -β (Reverb-hDKO) alters cholesterol and lipid metabolism in hepatocytes as well as rhythmic gene expression in nonparenchymal cells (NPCs) of the liver. Here, we report that in fatty liver caused by diet-induced obesity (DIO), hepatocyte SREBP cleavage-activating protein (SCAP) was required for Reverb-hDKO-induced diurnal rhythmic remodeling and epigenomic reprogramming in liver macrophages (LMs). Integrative analyses of isolated hepatocytes and LMs revealed that SCAP-dependent lipidomic changes in REV-ERB-depleted hepatocytes led to the enhancement of LM metabolic rhythms. Hepatocytic loss of REV-ERBα and β (REV-ERBs) also attenuated LM rhythms via SCAP-independent polypeptide secretion. These results shed light on the signaling mechanisms by which hepatocytes regulate diurnal rhythms in NPCs in fatty liver disease caused by DIO.

| S-EPMC10104893 | biostudies-literature

Hepatocyte SREBP signaling mediates clock communication within the liver

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-04-03 | GSE206319 | GEO

The Autonomous Hepatocyte Clock Controls Acetaminophen Bioactivation and Chronotoxicity [Liver]

2013-08-30 | GSE34442 | GEO

The Autonomous Hepatocyte Clock Controls Acetaminophen Bioactivation and Chronotoxicity [Kidney]

Project description:The diurnal variation in acetaminophen (APAP) hepatotoxicity (“chronotoxicity”) is thought to be due to oscillations in xenobiotic metabolism that are influenced by the circadian phases of feeding or fasting. Because of APAP’s relevance to human poisoning, we set out to determine the relative contributions of the central clock in the SCN and the autonomous clock in the hepatocyte in modulating the chronotoxicity of APAP. Using a conditional null allele of Mop3 (ArntL, Bmal1) we are able to delete the clock from hepatocytes while keeping the central and other peripheral clocks intact (eg, those controlling food intake). Our data from this hepatocyte-null mouse model suggests that, while the central circadian clock modulates some detoxification pathways indirectly by driving activity patterns and feeding rhythms, the autonomous hepatocyte circadian clock controls major aspects of APAP bioactivation independent of feeding rhythms, possibly through transcriptional regulation of cytochrome p450-oxidoreductase (Por). 10-20 week old Mop3fxfx mice positive or negative for Cre-recombinase driven by the albumin promoter, housed in 12 hour light:12 dark, ad lib feeding and drinking conditions were sacrificed every four hours over two separte days beginning at ZT0. A two color, reference design experiment in which kidney RNA from at least 3 mice per timepoint were pooled and labeled with Cy3 and hybridized according to Agilent protocols against a reference pool of RNA madeup from respective tissue taken from 10 week Mop3fxfx and Mop3fxfxCreAlb mice which was labeled with Cy5.

2013-08-30 | E-GEOD-34443 | biostudies-arrayexpress

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