Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of KHSRP acetylation on gene expression in LNCaP cells

ABSTRACT: Effect of KHSRP acetylation on gene expression in LNCaP cells

PROVIDER: PRJNA851059 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19754400_1.fastq.gz	Fastqsanger.gz
	SRR19754400_2.fastq.gz	Fastqsanger.gz
	SRR19754401_1.fastq.gz	Fastqsanger.gz
	SRR19754401_2.fastq.gz	Fastqsanger.gz
	SRR19754402_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Effect of KHSRP acetylation on gene expression in LNCaP cells

Project description:We established LNCaP cells in wihch KHSRP was knocked down along with LNCaP cells with silenced KHSRP and re-introduced HA-tagged KHSRP-WT/K205R.RNA-seq was carried out in the stable LNCaP cell lines to determine the underlying mechanism of KHSRP acetylation in PCa tumorigenesis. We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 different cells.

2024-05-27 | GSE206486 | GEO

Effect of KHSRP KO in adult mouse neocortex (CTX)

Project description:Effect of KHSRP KO in adult mouse neocortex (CTX)

| PRJNA698976 | ENA

effect of depletion of PRCAT71 and KHSRP on gene expression in prostate cancer cells

Project description:Mounting evidence indicates that long non-coding RNAs (lncRNAs) play vital roles in tumorigenesis and progression of cancers. However, the functions and regulatory mechanisms of lncRNAs in prostate cancer (PCa) are still largely unknown. In this study, we discovered a PCa-specific lncRNA, PRCAT71, significantly highly expressed in metastatic and primary PCa compared to benign prostate tissues. Silencing PRCAT71 inhibited cancerous properties of PCa cells, as well as androgen receptor (AR) signaling. Mechanismly, PRCAT71 acts as a scaffold to recruit KH-type splicing regulatory protein (KHSRP) to AR mRNA and stabilize AR mRNA. Furthermore, PRCAT71 is transcriptionally regulated by AR, thus forming a positive regulatory loop between AR and PRCAT71 in PCa. Our findings demonstrate that the PRCAT71-KHSRP-AR axis is a promising therapeutic target to treat PCa.

2024-10-16 | GSE240059 | GEO

effect of depletion of PRCAT71 and KHSRP on gene expression in prostate cancer cells

Project description:effect of depletion of PRCAT71 and KHSRP on gene expression in prostate cancer cells

| PRJNA1002000 | ENA

lncRNA-PCAT1 knockdown effect on the gene expression of androgen independent LNCaP (LNCaP-AI) cell line

Project description:lncRNA-PCAT1 knockdown effect on the gene expression of androgen independent LNCaP (LNCaP-AI) cell line

| PRJNA512282 | ENA

The effect of MEL-6 on gene expression in LNCaP cells

Project description:The effect of MEL-6 on gene expression in LNCaP cells

| PRJNA1017839 | ENA

DHT (androgen) effect on the gene expression of LNCaP cell line

Project description:DHT (androgen) effect on the gene expression of LNCaP cell line

| PRJNA686648 | ENA

Effect of overexpression of LINC01518 on gene expression in prostate cancer lncap cells

Project description:LINC01518 is differentially expressed in prostate cancer, but the exact role and potential mechanisms are unknown. We overexpressed LINC01518 in prostate cancer lncap cells and examined the effect of LINC01518 on gene expression profiles by RNA sequencing

2024-10-07 | GSE242535 | GEO

lncRNA-PCAT1 knockdown effect on the gene expression of androgen independent LNCaP (LNCaP-AI) cell line

Project description:We generated and characterized an androgen-independent LNCaP-AI cell line by long-term culture of androgen-dependent LNCaP cells in RPMI-1640 medium containing charcoal-stripped serum. This approach used to generate the line mimics the castration resistant condition for treating prostate cancer, supporting the relevance of the LNCAP-AI cell line to Castration Resistant Prostate Cancer.

2019-01-01 | GSE124519 | GEO

Effect of overexpression of MEG3 on gene expression in prostate cancer lncap cells

Project description:Long non-coding RNA MEG3 is widely involved in tumor development. However, its role in prostate cancer is not very clear. We overexpressed MEG3 in prostate cancer lncap cells and characterized the effect of MEG3 on gene expression profiles by RNA sequencing

2024-10-07 | GSE242536 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data