Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparative analyses of DNA methylomes in the liver among three ruminants

ABSTRACT: Comparative analyses of DNA methylomes in the liver among three ruminants

PROVIDER: PRJNA851169 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Comparative analyses of DNA methylomes in the liver among three ruminants

Project description:This study is the first to report a genome-wide comparative DNA methylation map of liver in three ruminants using WGBS technology.

2022-09-15 | GSE206511 | GEO

Comparative gene expressions profiling of brain and muscle across ruminants

Project description:To describe the gene expression profile of brain and muscle across ruminants, we performed gene expression analysis of brain and muscle using RNA-seq data for three ruminants.

2024-02-07 | GSE213317 | GEO

Comparative epigenomic analyses of DNA methylomes and gene expression during ruminant evolution

Project description:This study is the first to report a genome-wide comparative DNA methylation map in three ruminants using WGBS technology.

2024-02-07 | GSE211353 | GEO

Analyses of methylomes of Bones in cattle

Project description:Analyses of methylomes of Bones in cattle

| PRJNA613277 | ENA

Analyses of methylomes of multiple tissues in cattle

Project description:Analyses of methylomes of multiple tissues in cattle

| PRJNA612978 | ENA

Comparative epigenomic analyses of DNA methylomes and gene expression during ruminant evolution

Project description:Comparative epigenomic analyses of DNA methylomes and gene expression during ruminant evolution

| PRJNA869947 | ENA

Comparative analyses of sperm DNA methylomes among three commercial pig breeds reveal vital hypomethylated regions associated with spermatogenesis and embryonic development

Project description:Comparative analyses of sperm DNA methylomes among three commercial pig breeds reveal vital hypomethylated regions associated with spermatogenesis and embryonic development

| PRJNA746554 | ENA

Evidence That Three Classes of Methylomes Specific for Stem, Somatic and Transformed Cells Are Set by Three Independent Mechanisms (Methyl-Seq)

Project description:Whole genome-bisulfite sequencing has revealed that methylomes differ dramatically in a cell type-specific manner. However, the global mechanisms of maintenance of DNA methylation patterns and their functional consequences are not clear. Using a combination of novel haplotype-resolved methylomes and publicly available data, we show that three distinct classes of methylomes that differ by the proportion of partially and highly methylated domains are characteristic of stem and progenitor, somatic and transformed cells. We provide evidence that three mechanisms can account for most of the differences between these three classes of methylomes. The first, protection of promoters and cis-acting regulatory elements from DNA methylation by DNA-binding proteins, keeps regulatory elements unmethylated. The second, DNA replication-associated maintenance of DNA methylation, is highly efficient in stem cells, moderately efficient in somatic cells, and very inefficient in transformed cells, and sets variable basal levels of methylation characteristic of the partially methylated domains of each cell type. The third, transcriptional elongation-associated gene-body DNA methylation is responsible for the formation of highly methylated domains in somatic and transformed cells. We show that partitioning of the genome into partially and highly methylated domains is associated with different mechanisms of gene silencing.

2019-07-23 | GSE84998 | GEO

Evidence That Three Classes of Methylomes Specific for Stem, Somatic and Transformed Cells Are Set by Three Independent Mechanisms (RNA-Seq)

2019-07-23 | GSE84999 | GEO

12 single-base resolution methylomes of three life stages using WGBS

Project description:12 single-base resolution methylomes of three life stages using WGBS

| PRJNA579962 | ENA