Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Molecular mechanism of MLF1 in AC16 cell line

ABSTRACT: Molecular mechanism of MLF1 in AC16 cell line

PROVIDER: PRJNA851990 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Molecular mechanism of MLF1 in AC16 cell line

Project description:Previous studies found that MLF1 mRNA levels tended to decline in aging hearts. Functional studies found that knockdown of MLF1 ameliorated the drug-induced cellular senescence phenotype. Here, we apply transcriptomics to explore the underlying molecular mechanisms.

2025-01-29 | GSE206754 | GEO

Molecular mechanism of EP300 in AC16 cell line

Project description:Molecular mechanism of EP300 in AC16 cell line

| PRJNA1085281 | ENA

The role of MLF1 on accessible chromatin in AC16 cell line

2025-01-29 | GSE207907 | GEO

The role of MLF1 on accessible chromatin in AC16 cell line

Project description:The role of MLF1 on accessible chromatin in AC16 cell line

| PRJNA857661 | ENA

Downregulation of MLF1 safeguards cardiomyocytes against senescence-associated chromatin opening

Project description:Previous studies found that MLF1 mRNA levels tended to decline in aging hearts. Functional studies found that knockdown of MLF1 ameliorated the drug-induced cellular senescence phenotype. Here, we apply CUT&Tag to explore the underlying molecular mechanisms.

2025-01-29 | GSE273659 | GEO

Molecular mechanism of EP300 in AC16 cell line

Project description:Functional studies found that knockdown of EP300 ameliorated the drug-induced cellular senescence phenotype. Here, we apply transcriptomics to explore the underlying molecular mechanisms.

2025-01-29 | GSE261096 | GEO

RNA sequencing of AC16 and AC16-CAR cells

Project description:RNA sequencing of AC16 and AC16-CAR cells

| PRJNA649286 | ENA

Targeted analysis of alternative protein isoforms in AC16 cells

Project description:AC16 cells (Human Cardiomyocyte Cell Line) were digested by trypsin and analyzed by parallel reaction monitoring.

2022-05-19 | PXD023563 | Pride

NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes

Project description:Nucleophosmin (NPM1) is either frequently mutated or subjected to chromosomal translocation in acute myeloid leukemia (AML). NPM protein is primarily located in the nucleus, but the recurrent NPMc+ mutation is characterized by cytoplasmic localization and leukemogenic properties. Similarly, the NPM-MLF1 translocation product favors the partial cytoplasmic retention of NPM. Regardless of their common cellular distribution, NPM-MLF1 malignancies engender different effects on hematopoiesis compared to NPMc+ counterparts, highlighting possible aberrant nuclear function(s) of NPM in NPMc+ AML. We performed a proteomics analysis and found that NPM and NPM-MLF1 interact with chromatin remodeling complexes of the ISWI family, as well as with NuRD and P/BAF complexes. Accordingly, NPM and NPM-MLF1 are recruited to transcriptionally active or repressed genes along with NuRD and P/BAF elements. Although the overall gene expression program in NPM knockdown cells is similar to that resulting from NPMc+ and is consistent with loss of nuclear function of NPM, NPM-MLF1 expression differentially altered gene transcription regulated by NPM. The abnormal gene regulation imposed by NPM-MLF1 is characterized by enhanced recruitment of NuRD to gene regulatory regions. Thus, different mechanisms orchestrate the deregulation of NPM function in NPMc+- versus NPM1-MLF1-associated leukemia.

2019-10-17 | GSE124495 | GEO

Desulfonatronum thiodismutans strain:MLF1

Project description:Desulfonatronum thiodismutans strain:MLF1 Genome sequencing

| PRJNA252861 | ENA