Project description:Adult male goldfish, exposed to estrogen (E2) implant, 1 day exposure See the following for further details; Marlatt VL, Martyniuk, CJ, Zhang, D, Xiong, H, Xia, X, Trudeau, VL, Moon, T. Tissue-specific auto-regulation of estrogen receptor subtypes and transcript profiling of estrogen-responsive genes in the neuroendocrine brain of male goldfish (Carassius auratus) exposed to 17beta-estradiol. J. Mol. Endocrinol. (accepted). Keywords: Estrogen effect on male goldfish hypothalamus, microarray
Project description:Carassius auratus complex formula (CACF) is composed of extracts from Carassius auratus, Rhizoma dioscoreae, Lycium chinense, and Rehmannia glutinosa Libosch. These ingredients are used to treat diabetes since ancient China. Previously, CACF elicits antidiabetic effects in streptozotocin-induced diabetic mouse models under high-fat diet treatment, reduces triglyceride levels, maintains blood sugar control, and enhances insulin sensitivity. However, the effects of CACF on anti-cancer and anti-inflammation and the underlying mechanism remain unknown. In this study, we revealed that CACF could be a promising therapeutic agent with multiple functions
