Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Circulating PMN-MDSCs correlates with poor prognosis in metastatic hormone sensitive prostate cancer

ABSTRACT: Circulating PMN-MDSCs correlates with poor prognosis in metastatic hormone sensitive prostate cancer

PROVIDER: PRJNA853305 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR19867250.fastq.gz	Fastqsanger.gz
	SRR19867251.fastq.gz	Fastqsanger.gz
	SRR19867253.fastq.gz	Fastqsanger.gz

Items per page:

1 - 3 of 3

Similar Datasets

Circulating PMN-MDSCs correlates with poor prognosis in metastatic hormone sensitive prostate cancer

Project description:Myeloid-derived suppressor cells are recognized as a immunosuppressive cells in cancer but the characteritics in prostate cancer have not yet been known. We analyzed MDSCs and immune cells by single cell RNA sequence to clarify their variationos in prostate cancer.

2022-06-30 | GSE207006 | GEO

Transcriptome comparison of PMN-MDSCs and and normal neutrophils

2023-06-26 | GSE199601 | GEO

White button mushroom intake modulates PMN-MDSCs, T, and NK cells’ function at the single cell level in prostate cancer patients

Project description:In prostate cancer patients following 3 months of white button mushroom consumption in freeze-dried tablet form, we observed the decline of circulating polymorphonuclear MDSCs (PMN-MDSCs), along with an increase of granzyme B positive CD8+ T cells and NK cells. Furthermore, single immune cell profiling of peripheral blood from WBM-treated patients revealed the transcriptional landscape of circulating immune cells. This methods showed a decrease in overall circulating PMN-MDSCs with suppression on the expression of STAT3/IRF1 and TGFβ signaling. Subclusters of PMN-MDSCs showed transcriptional profiles associated with "response to fungus", "neutrophil chemotaxis", "leukocyte aggregation", and "regulation of inflammatory response", which are associated with enhanced immune-modulated anti-tumor activity.

2024-10-16 | GSE266985 | GEO

White button mushroom intake modulates PMN-MDSCs, T, and NK cells’ function at the single cell level in prostate cancer patients (validation cohort)

2024-10-16 | GSE275574 | GEO

Transcriptome comparison of PMN-MDSCs and and normal neutrophils

Project description:Transcriptome comparison of PMN-MDSCs and and normal neutrophils

| PRJNA820788 | ENA

Expression data from MDSCs at different time points during tumor progression

Project description:Myeloid-derived suppressor cells (MDSCs) are increased by tumor-derived factors and suppress anti-tumor immunity. MDSCs obtained at a late time point after tumor injection had stronger suppressive activity than MDSCs obtained at an early time point, as measured by T cell proliferation assays. To find factors in MDSCs that change during tumor growth, we analyzed gene expression profiles from MDSCs at different time points after tumor injection. We found that immune response-related genes were down-regulated, but pro-tumor function-related genes were up-regulated in both Mo-MDSCs and PMN-MDSCs at the late time point. Among differentially expressed genes, FK506 binding protein 51 (FKBP51), which is a member of the immunophilin protein family and plays a role in immunoregulation, was increased in the Mo- and PMN-MDSCs isolated from the late time points. Experiments using siRNA and a chemical inhibitor of FKBP51 revealed that FKBP51 contributes to the regulation of the suppressive function of MDSCs by increasing iNOS, ARG1, and ROS levels and enhancing NF-kappaB activity. Collectively, our data suggest that FKBP51 is a novel molecule that can be targeted to regulate the immunosuppressive function of MDSCs. To identify the factors that licensed MDSCs to be more suppressive as tumors grow, we analyzed gene expression profiles in the two subsets of MDSCs at different time points (3wks, 6wks) during tumor progression. CD11b+Ly-6C(high)Ly-6G(low) Mo-MDSCs and CD11b+Ly-6C(low)Ly-6G(high) PMN-MDSCs were sorted from pooled spleens of naÃ¯ve mice and Her-2/CT26 tumor-bearing mice. Total RNA was purified and gene expression was analyzed by the Affymetrix GeneChipÂ® Mouse Gene 1.0 ST Array.

2012-03-29 | E-GEOD-35398 | biostudies-arrayexpress

Whole genome expression profile of human decidual PMN-MDSC and autologous neutrophils in normal pregnancy

Project description:It is suggested that decidual polymorphonuclear myeloid-derived suppressor cell (PMN-MDSCs) are a group of activated suppressive neutrophils. Decidual microenvironment can facilitate circulating neutrophils with phenotypes and functions of PMN-MDSCs. The mechanism of PMN-MDSCs differentiation induced by decidual microenvironment has not been fully understood. Here we performed whole genome expression profile of 3 decidual PMN-MDSCs and autologous neutrophils from normal early pregnancy. Total RNA were extracted. The arrays were scanned by the Agilent Scanner G2505C. There were differences of gene expression pattern between decidual PMN-MDSCs and autologous neutrophils in early normal pregnancy.

2022-05-13 | GSE192850 | GEO

Transcriptome comparsion of WT and CD300ld KO PMN-MDSC

Project description:Polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC), also named pathologically activated neutrophil, is a critical component of tumor microenvironment (TME), playing crucial roles in tumor progression and therapy resistance. CD300ld is specifically expressed in normal neutrophils and is upregulated in PMN-MDSCs upon tumor bearing. CD300ld knockout (KO) inhibits the development of multiple tumor types in a PMN-MDSC-dependent manner. Here, we compared the transcriptome of PMN-MDSCs from WT mice and CD300ld KO mice.

2023-06-26 | GSE199602 | GEO

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis

Project description:19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis

| PRJNA606780 | ENA

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-022060)

Project description:19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-022060)

| PRJNA606782 | ENA