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M1BP RNAi during Drosophila flight myogenesis: Analyses at 2-day adult stage

ABSTRACT: M1BP RNAi during Drosophila flight myogenesis: Analyses at 2-day adult stage

PROVIDER: PRJNA854347 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19906233_1.fastq.gz	Fastqsanger.gz
	SRR19906233_2.fastq.gz	Fastqsanger.gz
	SRR19906234_1.fastq.gz	Fastqsanger.gz
	SRR19906234_2.fastq.gz	Fastqsanger.gz
	SRR19906235_1.fastq.gz	Fastqsanger.gz

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M1BP RNAi during Drosophila flight myogenesis: Analyses at 2-day adult stage

Project description:Oxidative metabolism is the predominant energy source for muscle contraction. How this is transcriptionally regulated during muscle development to accommodate different metabolic requirements and muscle types is largely unknown. We show that the formation of mitochondria cristae harbouring the respiratory chain is concomitant with a large-scale transcriptional upregulation of genes linked with oxidative phosphorylation (OXPHOS) during the middle of Drosophila flight muscle development. We further demonstrate using high-resolution imaging, transcriptomic and biochemical analyses that Motif-1-binding protein (M1BP) transcriptionally regulates the expression of genes encoding critical components for OXPHOS complex assembly and integrity. In the absence of M1BP, mitochondrial respiratory complexes are improperly assembled and aggregate in the mitochondrial matrix, triggering a strong protein quality control response. Together, this study provides the first insight into the transcriptional regulation of oxidative metabolism during Drosophila myogenesis and identifies M1BP as a novel player in this process.

2023-05-12 | GSE207238 | GEO

M1BP RNAi during Drosophila flight myogenesis: Analyses at 0h APF stage

Project description:M1BP RNAi during Drosophila flight myogenesis: Analyses at 0h APF stage

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M1BP RNAi during Drosophila flight myogenesis: Analyses at 64h APF stage

Project description:M1BP RNAi during Drosophila flight myogenesis: Analyses at 64h APF stage

| PRJNA854348 | ENA

M1BP RNAi during Drosophila flight myogenesis: Analyses at 48h APF stage

Project description:M1BP RNAi during Drosophila flight myogenesis: Analyses at 48h APF stage

| PRJNA854349 | ENA

M1BP RNAi during Drosophila flight myogenesis: Analyses at 0h APF stage

2023-05-12 | GSE207239 | GEO

M1BP RNAi during Drosophila flight myogenesis: Analyses at 64h APF stage

2023-05-12 | GSE207237 | GEO

M1BP RNAi during Drosophila flight myogenesis: Analyses at 48h APF stage

2023-05-12 | GSE207236 | GEO

Expression analysis of Drosophila S2R+ cells depleted of M1BP by RNAi

Project description:Microarray analysis of gene expression profiles in control and M1BP-depleted Drosophila S2R+ cells. The results of this analyses are reported in Li, J. and D.S. Gilmour (2013) The newly identified transcription factor M1BP ad GAGA factor orchestrate distinct mechanisms of transcriptional regulation on paused genes. The EMBO J, in press. Four biological replicates comparing total RNA isolated from M1BP-RNAi treated and LacZ-RNAi treated cells.

2013-08-13 | E-GEOD-46629 | biostudies-arrayexpress

Expression analysis of Drosophila S2R+ cells depleted of M1BP by RNAi

2013-08-13 | GSE46629 | GEO

Loss of Antp function in Drosophila flight muscle precursors : RNAi in larval wing disc-associated myoblasts

Project description:Muscle development and diversity require a large number of spatially and temporally regulated events controlled by transcription factors (TFs). Drosophila has long stood as a model organism to study myogenesis due to the highly conserved key TFs involved at all stages of muscle development, from specification to differentiation. While many studies focused on the diversification of Drosophila larval musculature, how distinct adult muscle types are generated is much less characterised. Here, we identify a novel essential regulator of Drosophila thoracic flight muscle development, the Hox TF Antennapedia (Antp). Correcting a long standing misconception that flight muscle development occurs without the input of Hox TFs, we show that Antp intervenes at several stages of adult flight muscle development, from the establishment of the progenitor pool in the embryo to myoblast differentiation in the early pupa. Furthermore, the precisely regulated clearance of Hox at the pupal stage in the developing indirect flight muscle fibers is required to allow for stretch-activated fibrillar muscle fate diversification that sets these flight muscles apart from all other adult tubular muscle types.

2024-10-23 | GSE268578 | GEO

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