Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Fusobacterium polymorphum strain:SSMR1 | isolate:29

ABSTRACT: Fusobacterium polymorphum strain:SSMR1 | isolate:29 Genome sequencing

PROVIDER: PRJNA855465 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Fusobacterium polymorphum strain:KCOM 1265

Project description:Fusobacterium polymorphum strain:KCOM 1265 Genome sequencing and assembly

| PRJNA416415 | ENA

Fusobacterium polymorphum ATCC 10953

Project description:Fusobacterium polymorphum ATCC 10953 Genome sequencing

| PRJNA178298 | ENA

Influence of dual-species coaggregation on transcriptional changes of Streptococcus gordonii and Fusobacterium nucleatum subsp. polymorphum

Project description:Interspecies coaggregation promotes transcriptional changes of oral bacteria, contributing to the development of structurally balanced biofilms as well as oral diseases such as periodontitis. Streptococcus gordonii (S. gordonii) is an early colonizer of the oral cavity, and Fusobacterium nucleatum (F. nucleatum) may act as a bridge adhering to both early and late oral colonizers. These two species were commonly detected in healthy and periodontitis-diseased oral sites and could interact with immune cells such as macrophages. However, little research explored how intergeneric coaggregation affected transcriptional changes in S. gordonii and F. nucleatum subsp. polymorphum and how these gene changes might affect both species’ pathogenicity. The present study investigated transcriptional changes of both species in response to dual-species physical association using dual RNA-seq. Results indicated that after 30-min dual-species coaggregation, 148 genes were significantly up-regulated, and 124 genes were significantly down-regulated in S. gordonii. A total of 154 genes were significantly down-regulated, and 10 genes were significantly up-regulated in F. nucleatum subsp. polymorphum. A majority of up-regulated S. gordonii genes were involved in the biosynthesis and export of cell-wall proteins and the pathway of carbohydrate metabolism, and a group of down-regulated S. gordonii genes were associated with fatty acid biosynthesis and peptidoglycan biosynthesis. The transcriptome profiles indicated that the interspecies coaggregation led to a reduced level of DNA repair and lipopolysaccharides virulence in F. nucleatum subsp. polymorphum. The present study revealed that dual-species coaggregation induced a wide array of gene changes in S. gordonii and F. nucleatum subsp. polymorphum, enhancing S. gordonii’s adherence ability and attenuating F. nucleatum subsp. polymorphum's ability to produce LPS.

2021-05-20 | GSE164282 | GEO

Fusobacterium polymorphum strain:ChDC F306

Project description:Genome sequencing of Fusobacterium nucleatum subsp. polymorphum KCOM 1272

| PRJNA270146 | ENA

Fusobacterium polymorphum strain:KCOM 1265

Project description:Genome sequencing of Fusobacterium nucleatum subsp. polymorphum KCOM 1265

| PRJNA657090 | ENA

Fusobacterium polymorphum strain:KCOM 1001

Project description:Genome sequencing of Fusobacterium nucleatum subsp. polymorphum KCOM 1001 (=ChDC F119)

| PRJNA386424 | ENA

Fusobacterium polymorphum strain:KCOM 1248 (=ChDC F113)

Project description:Genome sequencing of Fusobacterium nucleatum subsp. polymorphum KCOM 1248