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Transcriptonal and epigenetic profiling of neuroblastoma cells based on CD49b expression

ABSTRACT: Transcriptonal and epigenetic profiling of neuroblastoma cells based on CD49b expression

PROVIDER: PRJNA855951 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR19991119_1.fastq.gz	Fastqsanger.gz
	SRR19991119_2.fastq.gz	Fastqsanger.gz
	SRR19991120_1.fastq.gz	Fastqsanger.gz
	SRR19991120_2.fastq.gz	Fastqsanger.gz
	SRR19991121_1.fastq.gz	Fastqsanger.gz

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Transcriptonal and epigenetic profiling of neuroblastoma cells based on CD49b expression

Project description:This study was undertaken to assess heterogeneity within neuroblastoma cell populations, and to assess whether the integrin CD49b can distinguish different neuroblastoma phenotypes. Methods: We performed bulk RNA sequencing on Neuro-2a and SH-SY5Y neuroblastoma cells sorted based on CD49b expression, and CUT&RUN for H3K4me1 and H3K27ac on Neuro-2a cells sorted based on CD49b expression. Results: We find that CD49b expression identifies transcriptionally distinct neuroblastoma cell populations. High CD49b expression marks cells expressing mesenchymal genes, while lack of CD49 denotes cells expression neuronal genes. CUT&RUN analysis shows that CD49b distinguishes cells with distinct enhancer and super enhancer profiles. Conclusion: RNA sequencing and CUT&RUN demonstrate that neuroblastoma cell lines include heterogeneous populations.

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