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Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management

ABSTRACT: Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management

PROVIDER: PRJNA856276 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR20002200.fastq.gz	Fastqsanger.gz
	SRR20002300.fastq.gz	Fastqsanger.gz
	SRR20002101.fastq.gz	Fastqsanger.gz
	SRR20002201.fastq.gz	Fastqsanger.gz
	SRR20002301.fastq.gz	Fastqsanger.gz

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Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management

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Project description:Liquid biopsy approaches offer a promising technology for early and minimally invasive cancer detection. Tumor-educated platelets (TEPs) have emerged as a promising liquid biopsy biosource for the detection of various cancer types. In this study, we processed and analyzed the TEPs collected from 466 Non-small Cell Lung Carcinoma (NSCLC) patients and 410 asymptomatic individuals (controls) using the previously established thromboSeq protocol. We developed a novel particle-swarm optimization machine learning algorithm which enabled the selection of an 881 RNA biomarker panel (AUC 0.88). Herein we propose and validate in an independent cohort of samples (n = 558) two approaches for blood samples testing: one with high sensitivity (95% NSCLC detected) and another with high specificity (94% controls detected). Our data explain how TEP-derived spliced RNAs may serve as a biomarker for minimally-invasive clinical blood tests, complement existing imaging tests, and assist the detection and management of lung cancer patients.

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