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P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence

ABSTRACT: P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence

PROVIDER: PRJNA857100 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR20046804_1.fastq.gz	Fastqsanger.gz
	SRR20046804_2.fastq.gz	Fastqsanger.gz
	SRR20046805_1.fastq.gz	Fastqsanger.gz
	SRR20046805_2.fastq.gz	Fastqsanger.gz
	SRR20046806_1.fastq.gz	Fastqsanger.gz

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P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells.

Project description:Glioma stem cells (GSC) exhibit plasticity in response to environmental and therapeutic stress leading to tumor recurrence, but the underlying mechanisms remain largely unknown. Here, we employ single-cell and whole transcriptomic analyses to uncover that radiation induces a dynamic shift in functional states of glioma cells allowing for acquisition of vascular endothelial-like and pericyte-like cell phenotypes. These vascular-like cells provide trophic support to promote proliferation of tumor cells, and their selective depletion results in reduced tumor growth post-treatment in vivo. Mechanistically, the acquisition of vascular-like phenotype is driven by increased chromatin accessibility and H3K27 acetylation in specific vascular genes allowing for their increased expression post-treatment. Blocking P300 histone acetyltransferase activity reverses the epigenetic changes induced by radiation and inhibits the adaptive conversion of GSC into vascular-like cells and tumor growth. Our findings highlight a role for P300 in radiation-induced stress response, suggesting a therapeutic approach to prevent glioma recurrence.

| S-EPMC9582000 | biostudies-literature

P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence [ATAC_SeqIRC646]

Project description:Purpose: The goal of the experiment is to determine chromatin accessibility changes induced by radiation and treatment with P300 HAT inhibitor C646 in gliomaspheres by ATAC-sequencing

2022-09-09 | GSE207807 | GEO

P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence [RNA_seq IR_C646]

Project description:Purpose: The goal of the experiment is to determine if blocking P300 HAT activity with a small molecule inhibitor C646 reverses the radiation-induced changes in gliomaspheres

2022-09-09 | GSE207728 | GEO

P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-09-09 | GSE207808 | GEO

P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence [ATAC_SeqIRC646]

Project description:P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence [ATAC_SeqIRC646]

| PRJNA857102 | ENA

P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence [RNA_seq_IR]

Project description:P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence [RNA_seq_IR]

| PRJNA856890 | ENA

P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence [ATAC_Seq_IR]

Project description:P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence [ATAC_Seq_IR]

| PRJNA857103 | ENA

P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence [RNA_seq IR_C646]

Project description:P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence [RNA_seq IR_C646]

| PRJNA856889 | ENA

P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence [scRNAseq in vitro]

Project description:P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence [scRNAseq in vitro]

| PRJNA856892 | ENA

P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence [scRNA-seq in vivo]

Project description:P300-mediated adaptive conversion of glioma stem cells to vascular-like cells in response to therapeutic stress promotes tumor recurrence [scRNA-seq in vivo]

| PRJNA856891 | ENA

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