Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Direct Reprogramming of Fibroblasts into Functional Mammary Epithelial cells by small molecules (bulk miRNA-seq)

ABSTRACT: Direct Reprogramming of Fibroblasts into Functional Mammary Epithelial cells by small molecules (bulk miRNA-seq)

PROVIDER: PRJNA857651 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR20076300.fastq.gz	Fastqsanger.gz
	SRR20076301.fastq.gz	Fastqsanger.gz
	SRR20076302.fastq.gz	Fastqsanger.gz
	SRR20076303.fastq.gz	Fastqsanger.gz
	SRR20076304.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Direct Reprogramming of Fibroblasts into Functional Mammary Epithelial cells by small molecules

Project description:Direct Reprogramming of Fibroblasts into Functional Mammary Epithelial cells by small molecules

| PRJNA597354 | ENA

Direct Reprogramming of Fibroblasts into Functional Mammary Epithelial cells by small molecules (bulk miRNA-seq)

Project description:Mammary epithelial cells (MECs), the only cell type which could be capable of secreting milk in mammary gland, can be applied for the generation of transgenic mammary cell/gland bioreactor. However, continuously achieving large amount of high-quality goat MECs by non-invasion method, especially prepuberal MECs, in vitro has been a challenge. Here, we show that a small molecules cocktail enables the in vitro generation of chemically-induced mammary epithelial cells (CiMECs) with milk-secreting properties from goat ear fibroblasts. The properties of CiMECs were highly similar to those of naturally isolated MECs. Notably, the CiMECs lineage reprogramming process may partially imitate the MECs developmental process from embryonic to milk-secreting stages. Interestingly, fibroblasts were firstly reversed back to embryonic ectoderm/surface ectoderm-like state. Our findings constitute a substantial step toward further promoting the application of transgenic mammary bioreactors, moreover, also offer a new strategy for obtaining other cell types by reprogrammed fibroblasts.

2024-06-11 | GSE207893 | GEO

Direct Reprogramming of Fibroblasts into Functional Mammary Epithelial cells by small molecules (miRNAseq)

Project description:Direct Reprogramming of Fibroblasts into Functional Mammary Epithelial cells by small molecules (miRNAseq)

| PRJNA597880 | ENA

Direct Reprogramming of Fibroblasts into Functional Mammary Epithelial cells by small molecules (RNAseq)

Project description:Direct Reprogramming of Fibroblasts into Functional Mammary Epithelial cells by small molecules (RNAseq)

| PRJNA597359 | ENA

Direct Reprogramming of Fibroblasts into Functional Mammary Epithelial cells by small molecules (scRNAseq)

Project description:Direct Reprogramming of Fibroblasts into Functional Mammary Epithelial cells by small molecules (scRNAseq)

| PRJNA597358 | ENA

Direct Reprogramming of Fibroblasts into Functional Mammary Epithelial cells by small molecules (lncRNAseq)

Project description:Direct Reprogramming of Fibroblasts into Functional Mammary Epithelial cells by small molecules (lncRNAseq)