Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death.

ABSTRACT: Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death.

PROVIDER: PRJNA857899 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR20084037.fastq.gz	Fastqsanger.gz
	SRR20084038.fastq.gz	Fastqsanger.gz
	SRR20084538_1.fastq.gz	Fastqsanger.gz
	SRR20084538_2.fastq.gz	Fastqsanger.gz
	SRR20084039.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 19

Similar Datasets

Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death [scRNA-seq]

Project description:Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death [scRNA-seq]

| PRJNA857905 | ENA

Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death [RNA-seq]

Project description:Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death [RNA-seq]

| PRJNA857906 | ENA

Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death [scRNA-seq]

Project description:In humans, most neurons are born during embryonic development and have to persist throughout the entire lifespan of an individual. Thus, human neurons have to develop elaborate survival strategies to protect against accidental cell death. We set out to decipher the developmental adaptations resulting in neuronal resilience. We demonstrate that, during the time course of maturation, human neurons install a complex and complementary anti-apoptotic signaling network. This includes i.) a downregulation of central proteins of the intrinsic apoptosis pathway including several caspases, ii.) a shift in the ratio of pro- and anti-apoptotic BCL-2 family proteins, and iii.) an elaborate regulatory network resulting in upregulation of the inhibitor of apoptosis protein (IAP) XIAP. Together, these adaptations strongly increase the threshold for apoptosis initiation when confronted with a wide range of cellular stressors. Our results highlight how human neurons are endowed with complex and redundant preemptive strategies to protect against stress and cell death.

2022-07-15 | GSE207985 | GEO

Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death [RNA-seq]

2022-07-15 | GSE207984 | GEO

Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death.

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-07-15 | GSE207986 | GEO

ChAHP and ChAHP2 control diverse retrotransposons by complementary activities

Project description:ChAHP and ChAHP2 control diverse retrotransposons by complementary activities

| PRJNA1063746 | ENA

Molecular signature for anastasis, recovery from the brink of apoptotic cell death

Project description:Cells can survive effector caspase (caspase 3/7) activation in response to transient apoptotic stimuli, a process named anastasis. To characterize the molecular events that occur during anastasis, we performed whole transcriptome RNA sequencing of untreated, apoptotic, and recovering cells. We found that anastasis is an active, two-stage program with unique transcriptional profiles in each stage. We also identified 10 genes that specific to the early stage of anastasis.

2017-07-31 | GSE86480 | GEO

ChAHP and ChAHP2 control diverse retrotransposons by complementary activities [ATAC-seq]

Project description:ChAHP and ChAHP2 control diverse retrotransposons by complementary activities [ATAC-seq]

| PRJNA1063742 | ENA

ChAHP and ChAHP2 control diverse retrotransposons by complementary activities [ChIP-seq]

Project description:ChAHP and ChAHP2 control diverse retrotransposons by complementary activities [ChIP-seq]

| PRJNA1063744 | ENA

ChAHP and ChAHP2 control diverse retrotransposons by complementary activities [RNA-seq]

Project description:ChAHP and ChAHP2 control diverse retrotransposons by complementary activities [RNA-seq]

| PRJNA1063745 | ENA