Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Subcapsular sinus macrophages promote melanoma metastasis in the sentinel lymph nodes by releasing IL-1α, which upregulates STAT3 signalling in the tumour

ABSTRACT: Subcapsular sinus macrophages promote melanoma metastasis in the sentinel lymph nodes by releasing IL-1α, which upregulates STAT3 signalling in the tumour

PROVIDER: PRJNA858846 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Subcapsular sinus macrophages promote melanoma metastasis in the sentinel lymph nodes by releasing IL-1α, which upregulates STAT3 signalling in the tumour

Project description:We analyzed the expression of multiple genes involved in immunosuppressive and exhaustion pathways in sentinel lymph nodes (sLN) isolated from mice previously depleted of macrophages (CLL treated) and we compared them with non-depleted animals.

2022-08-25 | GSE208247 | GEO

Phocoena sinus

Project description:Phocoena sinus overview

| PRJNA558129 | ENA

Oribacterium sinus

Project description:Oribacterium sinus overview

| PRJNA161641 | ENA

Phocoena sinus

Project description:Phocoena sinus (Vaquita) genome assembly, mPhoSin1

| PRJNA560233 | ENA

Phocoena sinus

Project description:Phocoena sinus whole genome raw sequence reads

| PRJNA751981 | ENA

Comparison of DNA methyltransferase-1 (Dnmt1) deleted urogenital sinus epithelium compared to wildtype urogenital sinus epithelium

Project description:Dnmt1 is an important regulator of tissue development and differentiation. To assess the effects of epithelium Dnmt1 deletion in the developing urogenital sinus (precursor of the urethra and prostate in males), we isolated urogenital sinus epithelial tissue from Dnmt1 deleted mouse embryos and wildtype mouse embryos. The transcriptomes were analyzed by RNA-seq

2018-12-31 | GSE121086 | GEO

Alectinib Induces Sinus Bradycardia through Inhibiting Cacna1d Expression, Mediating Electro-Dysfunction in Sinus Node

Project description:Alectinib is the first-line therapy for anaplastic lymphoma kinase rearranged non-small cell lung cancer. Sinus node bradycardia as a major adverse cardiac event still widely impact patient’s quality of life. However, the underlying mechanism of alectinib induce sinus bradycardia (AISB) remains elusive. The aim of this study was to reveal the pathogenesis of the AISB in a rat model including the electrophysiology alterations and the molecular basis

2024-07-31 | GSE273570 | GEO

human sinus microbiome

Project description:human sinus microbiome Raw sequence reads

| PRJNA599016 | ENA

Sinus Microbiome Plays a Primary Role in Rhinosinusitis

Project description:Persistent mucosal inflammation and microbial infection are characteristic of Chronic Rhinosinusitis (CRS). Though mucosal microbiota dysbiosis is a characteristic feature of other chronic inflammatory diseases, the relationship between sinus microbiota composition and CRS is unknown. Here we demonstrate, using comparative microbiome profiling of a cohort of CRS patients and healthy subjects, that the sinus microbiota of CRS patients exhibit significantly reduced bacterial diversity. Characteristic of this community collapse is the depletion of multiple, phylogenetically distinct, Lactic Acid Bacteria and the concomitant increase in relative abundance of a single species, Corynebacterium tuberculostearicum. Recapitulating the conditions observed in our human cohort in a murine model confirmed the pathogenic potential of C. tuberculostearicum and the critical necessity for a replete mucosal microbiota to protect against this species. Moreover, we provide evidence that Lactobacillus sakei, identified from our comparative microbiome analyses as a potentially protective species, affords defense against C. tuberculostearicum sinus infection, even in the context of a depleted sinus bacterial community. These studies demonstrate that sinus mucosal health is highly dependent on the composition of the resident microbiota, and identifies a new sino-pathogen and a strong bacterial candidate for therapeutic intervention.

2012-08-01 | GSE37850 | GEO

Sinus Microbiome Plays a Primary Role in Rhinosinusitis

2012-07-31 | E-GEOD-37850 | biostudies-arrayexpress