Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CircRNA Microarray analysis of hippocampus from mouse treated by HFD

ABSTRACT: circRNA Microarray analysis of hippocampus from mouse treated by HFD

PROVIDER: PRJNA859511 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

circRNA Microarray analysis of hippocampus from mouse treated by HFD

Project description:To explore the potential mechanism linking circRNAs in Obesity-associated cognitive impairment induced by a longtime high-fat diet. The male mouse was treated by HFD up to16 weeks . Then the hippocaum tissues was isloated and circRNA Microarray analysis was applied. The expression profiles of hippocaum from mouse treated with HFD changed and 2 circRNA (mmu-circRNA-004797,mmu-circRNA-21040) from this signature was quantified by real-time PCR, confirming high-fat diet can change the profiles of circRNAs of hippocaum from mouse and may participated in the obesity associated cognitive impairment.

2022-09-07 | GSE208344 | GEO

CLL plasma circRNA microarray

Project description:CLL plasma circRNA microarray

| PRJNA543779 | ENA

circRNA sequencing facilitates quantitative analysis of CUS mice hippocampus and Control mice hippocampus

Project description:The goal of this study is to seek the potential circular RNAs (circRNAs), which express differently between control group and chronic unpredictable stress (CUS) group mouse hippocampus, involved in major dipresssion disorder (MDD) by high-throughput sequencing. QPCR was preformed to identify the circRNAs trend. CircRNAs are a class of RNAs in the eukaryotic transcriptome. The function and explicit downstream mechanisms of circRNA regulated in maior depression disorser remain unclear. To further investigate the potential role of circRNAs in MDD, we performed human and mouse homology screening on circRNA sequences using the Basic Local Alignment Search Tool on the NCBI website. CircSTAG1, a homologous human and mouse circRNA, was found downregulated in circRNA high-throughput sequencing. Our study represents the first detailed analysis of circRNA expressing differently in CUS mouse hippocampus by high-throughput sequencing.

2022-08-02 | GSE135343 | GEO

Identifying circRNA-associated-ceRNA networks in the hippocampus of Aß1-42-induced Alzheimer's disease-like rats using microarray analysis (circRNA)

Project description:Identifying circRNA-associated-ceRNA networks in the hippocampus of Aß1-42-induced Alzheimer's disease-like rats using microarray analysis (circRNA)

| PRJNA529882 | ENA

The microarray analysis of hippocampus in aged-mice treated with D-allose

Project description:The microarray analysis of hippocampus in aged-mice treated with D-allose

| PRJNA1126227 | ENA

LncRNA and circRNA expression profiles of Aβ25-35-induced AD mice hippocampus treated with Tripterygium Glycoside

Project description:Tripterygium glycosides (TG) was reported to have effect of ameliorating Alzheimer's disease (AD). However, the mechanism is not clear. We aimed to investigate the lncRNAs and circRNAs expression profiles of AD treated with TG by using microarray. LncRNAs, mRNA and circRNA in 3 AD mice and 3 AD+TG mice hippocampal were detected by microarray. The most differentially expressed lncRNAs, mRNA and circRNA in AD+TG group were screened. The differentially expressed lncRNAs and circRNAs were analyzed for GO enrichment and KEGG pathway. Co-expression analysis of lncRNAs and mRNA was performed by calculating correlation coefficients. Protein-protein interaction (PPI) network analysis was performed on mRNAs using STRING. LncRNA-target-TFs network were analyzed by Network software. CircRNA-mirNA network were conducted by Cytoscape software. A total of differentially expressed 661 lncRNAs, 64 circRNAs and 503 mRNAs were detected in AD mice treated with TG. The Pou4f1, Egr2, Mag, and Nr4a1 were the hub genes in the PPI network. The KEGG results showed the mRNAs that co-expressed with lncRNAs were enriched in TNF, PI3K-Akt, and Wnt signaling pathway. lncRNA-target-TFs network analysis indicated the TFs including Cebpa, Zic2, and Rxra were the most likely to regulate the detected lncRNAs. The circRNA-miRNA interaction network indicated 275 miRNAs may bind to the 64 circRNAs. In conclusion, the findings supplied a novel perspective for AD pathogenesis. And the detected lncRNAs, mRNAs, and circRNAs might be novel therapeutics targets for AD.

2022-05-30 | GSE204817 | GEO

CLL plasma circRNA microarray

Project description:To identify a novel circRNA which could serve as a plasma biomarker and explore its function and molecular mechanism as well as clinical significance in chronic lymphocytic leukemia (CLL) we performed circRNA microarray analysis.

2021-03-11 | GSE131469 | GEO

The gene microarray of digoxin on high-fat diet (HFD) induced changes in liver tissue

Project description:The goals of this study are to measure the microarray profiling of digoxin treated group versus vehicle control group in a 12 weeks HFD induced gene changes in liver tissue. The 'WT_LIVER" samples are from mice fed normal chow and not treated with digoxin, and the "HFD-WT" samples are from mice fed a high-fat diet and not treated with digoxin.

2018-01-08 | GSE108839 | GEO

The angiogenic role of circRNA-007371 in liver fibrosis [circRNA Microarray]

Project description:The angiogenic role of circRNA-007371 in liver fibrosis [circRNA Microarray]

| PRJNA904333 | ENA

J_093015-circRNA-33 AS-CR-005 Human CircRNA V2 microarray 01272016

Project description:J_093015-circRNA-33 AS-CR-005 Human CircRNA V2 microarray 01272016

| PRJNA487535 | ENA