Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Unraveling the role of human TSC-specific TFs [ChIP-Seq]

ABSTRACT: Unraveling the role of human TSC-specific TFs [ChIP-Seq]

PROVIDER: PRJNA859682 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR20280973.fastq.gz	Fastqsanger.gz
	SRR20280974.fastq.gz	Fastqsanger.gz
	SRR20280975.fastq.gz	Fastqsanger.gz
	SRR20280976.fastq.gz	Fastqsanger.gz
	SRR20280977.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 15

Similar Datasets

Unraveling the role of human TSC-specific TFs

Project description:Unraveling the role of human TSC-specific TFs

| PRJNA860294 | ENA

Unraveling the role of human TSC-specific TFs [RNA-Seq]

Project description:Unraveling the role of human TSC-specific TFs [RNA-Seq]

| PRJNA860305 | ENA

Unraveling the role of human TSC-specific TFs [ChIP-Seq]

Project description:Orchestrated actions of tissue-specific enhancers and transcription factors (TFs) govern the development of the placenta which is an essential organ to support the growth of the fetus during pregnancy. However, human trophoblast stem cells (TSCs)-specific enhancers, TFs, and the mechanisms by which TFs modulate placental development are poorly understood. Here we investigated enhancers, super-enhancers (SE), SE-associated genes in human TSC using RNA-seq and ChIP-seq to interrogate the roles of SE-TFs in human TSCs.

2023-03-22 | GSE208361 | GEO

Unraveling the role of human TSC-specific TFs [RNA-Seq]

2023-03-22 | GSE208538 | GEO

Unraveling the role of human TSC-specific TFs

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-03-22 | GSE208539 | GEO

EOMES safeguards TSC chromatin accessibility by directing BRG1 to TSC-associated loci [ATAC-seq]

Project description:EOMES is an essential transcription factor (TF) for murine trophoblast stem cell (TSC) maintenance. Despite that, the details of EOMES' function at the molecular level remain obscure. Here, we carried out rapid immunoprecipitation and mass spectrometry of endogenous protein (RIME) to identify TSC-specific protein interactors on EOMES. In addition to other established TFs involved in TSC maintenance, we found that EOMES interacts with several chromatin remodeller subunits, including BRG1. By exploiting an Eomes-degron system, we acutely depleted EOMES protein in TSCs and in parallel inhibited BRG1 function with small molecule BRM014. EOMES depletion and BRG1 inhibition resulted in reduced accessibility at largely overlapping genomic regions associated with TSC-related loci. Additionally, EOMES depletion results in misregulation of genes essential for TSC maintenance and function, as well as genes encoding cytoskeletal, cell-cell interaction and matricellular components.

2025-05-19 | GSE276039 | GEO

EOMES safeguards TSC chromatin accessibility by directing BRG1 to TSC-associated loci [RNA-seq]

2025-05-19 | GSE276261 | GEO

EOMES safeguards TSC chromatin accessibility by directing BRG1 to TSC-associated loci [CUT&RUN]

2025-05-19 | GSE276042 | GEO

Peg10 regulation of TSC differentiation

Project description:Peg10 regulation of TSC differentiation

| PRJNA504005 | ENA

Spatial transcriptomics of TSC angiomyolipoma

Project description:Spatial transcriptomics of TSC angiomyolipoma

| PRJNA867369 | ENA