Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

DNA hypomethylation restrains early antitumor immunity in prostate cancer [DNA methylation]

ABSTRACT: DNA hypomethylation restrains early antitumor immunity in prostate cancer [DNA methylation]

PROVIDER: PRJNA860307 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR20307800_1.fastq.gz	Fastqsanger.gz
	SRR20307800_2.fastq.gz	Fastqsanger.gz
	SRR20307900_1.fastq.gz	Fastqsanger.gz
	SRR20307900_2.fastq.gz	Fastqsanger.gz
	SRR20308000_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 906

Similar Datasets

DNA hypomethylation restrains early antitumor immunity in prostate cancer

Project description:DNA hypomethylation restrains early antitumor immunity in prostate cancer

| PRJNA860295 | ENA

DNA hypomethylation restrains early antitumor immunity in prostate cancer [RNAseq]

Project description:DNA hypomethylation restrains early antitumor immunity in prostate cancer [RNAseq]

| PRJNA860306 | ENA

DNA hypomethylation restrains early antitumor immunity in prostate cancer [Nanopore]

Project description:DNA hypomethylation restrains early antitumor immunity in prostate cancer [Nanopore]

| PRJNA864844 | ENA

DNA hypomethylation restrains early antitumor immunity in prostate cancer [ChIP-seq and CUT&RUN]

Project description:DNA hypomethylation restrains early antitumor immunity in prostate cancer [ChIP-seq and CUT&RUN]

| PRJNA863247 | ENA

DNA hypomethylation restrains early antitumor immunity in prostate cancer [DNA methylation]

Project description:Cancer is characterized by hypomethylation-associated silencing of large chromatin domains, whose contribution to tumorigenesis is uncertain. Through high-resolution single cell DNA methylation sequencing in prostate cancer, we identify 40 core hypomethylation domains, consistently hypomethylated across tumor cells and arising at early stages of malignancy. Transcriptionally silenced genes within these domains are enriched for immune-related genes; nested among repressive domains are small loci with preserved methylation, encoding cell proliferation genes that escape silencing. Prominent among hypomethylation-silenced genes is a gene cluster harboring all five CD1 genes that present lipid antigens to NKT cells, and four IFI16-related interferon-inducible genes implicated in innate immunity. Re-expression of CD1 or IFI16 murine orthologs in immunocompetent mice abrogates prostate tumorigenesis, accompanied by activation of anti-tumor immunity. Thus, early epigenetic changes in cancer may shape tumorigenesis, targeting co-located genes within defined chromosomal loci. Hypomethylation domains are detectable in blood specimens enriched for circulating tumor cells.

2023-06-14 | GSE208447 | GEO

DNA hypomethylation restrains early antitumor immunity in prostate cancer [RNAseq]

2023-06-14 | GSE208448 | GEO

DNA hypomethylation restrains early antitumor immunity in prostate cancer [Nanopore]

2023-06-14 | GSE210260 | GEO

DNA hypomethylation restrains early antitumor immunity in prostate cancer [ChIP-seq and CUT&RUN]

2023-06-14 | GSE209967 | GEO

DNA hypomethylation confers enhanced immunity against parasitic nematodes in plants

Project description:Background: Epigenetic processes play an important role in the plant response to adverse environmental conditions. A role for DNA hypomethylation has recently been suggested in the pathogenic interaction between bacteria and plants, yet it remains unclear whether this phenomenon reflects a conserved and general plant immunity response. We therefore investigated the role of DNA methylation in the plant defence against damaging parasitic nematodes. Methods and results: Treatment of roots of rice (monocot plant) and tomato (dicot plant) by a nematode-associated molecular pattern (NAMP) from different parasitic nematodes revealed global DNA hypomethylation using ELISA based quantification, suggesting conservation among plants. Focusing on root-knot induced gall tissue in rice, the causal impact of hypomethylation on immunity was revealed by a significantly reduced plant susceptibility upon 5-Azacitidine treatment. Whole genome bisulfite sequencing revealed that hypomethylation was massively present in the CHH context, while absent for CpG or CHG nucleotide contexts. CHH hypomethylated regions were predominantly associated with gene promoter regions, which was not correlated with activated gene expression at the same time point, but rather showed a delayed effect on transcriptional gene activation. Finally, the relevance of CHH hypomethylation in plant defence was confirmed in rice mutants of the RNA-directed DNA methylation pathway (RdDM) and DDM1, which are known to be steering DNA methylation in CHH context. Conclusions: We demonstrated that DNA hypomethylation confers enhanced defence in rice towards root-parasitic nematodes and is likely to be part of the basal NAMP-triggered immunity response in plants.

2020-07-07 | GSE130064 | GEO

Noncanonical MAVS signaling restrains dendritic cell-driven antitumor immunity by inhibiting IL-12

Project description:Noncanonical MAVS signaling restrains dendritic cell-driven antitumor immunity by inhibiting IL-12

| PRJNA992397 | ENA