Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A Comprehensive Survey of C. elegans Argonaute Proteins Reveals Organism-wide Gene Regulatory Networks and Functions

ABSTRACT: A Comprehensive Survey of C. elegans Argonaute Proteins Reveals Organism-wide Gene Regulatory Networks and Functions

PROVIDER: PRJNA860627 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR20334700.fastq.gz	Fastqsanger.gz
	SRR20334701.fastq.gz	Fastqsanger.gz
	SRR20334702.fastq.gz	Fastqsanger.gz
	SRR20334703.fastq.gz	Fastqsanger.gz
	SRR20334704.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 147

Similar Datasets

A Comprehensive Survey of C. elegans Argonaute Proteins Reveals Organism-wide Gene Regulatory Networks and Functions [Argonaute IP]

Project description:A Comprehensive Survey of C. elegans Argonaute Proteins Reveals Organism-wide Gene Regulatory Networks and Functions [Argonaute IP]

| PRJNA860633 | ENA

A Comprehensive Survey of C. elegans Argonaute Proteins Reveals Organism-wide Gene Regulatory Networks and Functions [mutants]

Project description:A Comprehensive Survey of C. elegans Argonaute Proteins Reveals Organism-wide Gene Regulatory Networks and Functions [mutants]

| PRJNA860632 | ENA

A Comprehensive Survey of C. elegans Argonaute Proteins Reveals Organism-wide Gene Regulatory Networks and Functions [Argonaute IP]

Project description:Argonaute (AGO) proteins associate with small RNAs to direct their effector function on complementary transcripts. The nematode C. elegans contains an expanded family of 19 functional AGO proteins, many of which have not been fully characterized. In this work we systematically analyzed every C. elegans AGO, using CRISPR-Cas9 genome editing to introduce GFP::3xFLAG tags. We have characterized the expression patterns of each AGO throughout development, identified small RNA binding complements, and determined the effects of ago loss on small RNA populations and developmental phenotypes. Our analysis indicates stratification of subsets of AGOs into distinct regulatory modules, and integration of our data led us to uncover novel stress-induced fertility and pathogen response phenotypes due to ago loss.

2022-07-22 | GSE208700 | GEO

A Comprehensive Survey of C. elegans Argonaute Proteins Reveals Organism-wide Gene Regulatory Networks and Functions [mutants]

2022-07-22 | GSE208701 | GEO

A comprehensive survey of <i>C. elegans</i> argonaute proteins reveals organism-wide gene regulatory networks and functions.

Project description:Argonaute (AGO) proteins associate with small RNAs to direct their effector function on complementary transcripts. The nematode Caenorhabditis elegans contains an expanded family of 19 functional AGO proteins, many of which have not been fully characterized. In this work, we systematically analyzed every C. elegans AGO using CRISPR-Cas9 genome editing to introduce GFP::3xFLAG tags. We have characterized the expression patterns of each AGO throughout development, identified small RNA binding complements, and determined the effects of ago loss on small RNA populations and developmental phenotypes. Our analysis indicates stratification of subsets of AGOs into distinct regulatory modules, and integration of our data led us to uncover novel stress-induced fertility and pathogen response phenotypes due to ago loss.

| S-EPMC10101689 | biostudies-literature

A Comprehensive Survey of C. elegans Argonaute Proteins Reveals Organism-wide Gene Regulatory Networks and Functions

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-07-22 | GSE208702 | GEO

Comprehensive discovery of endogenous Argonaute binding sites in C. elegans

Project description:Comprehensive discovery of endogenous Argonaute binding sites in C. elegans

2009-11-24 | GSE19138 | GEO

Transcription profiling of C. elegans to identify comprehensive discovery of endogenous Argonaute binding sites

Project description:Comprehensive discovery of endogenous Argonaute binding sites in C. elegans Experiment Overall Design: Total RNA were extracted from whole alg-1(gk214) (alg-1(-)) and N2 (wildtype) worms and used to compare the expression profiles of genes that were targeted by ALG-1 protein.

2009-11-28 | E-GEOD-19138 | biostudies-arrayexpress

Argonaute proteins couple chromatin silencing to alternative splicing

Project description:This SuperSeries is composed of the following subset Series: GSE39746: Argonaute proteins couple chromatin silencing to alternative splicing (exon array) GSE39748: Argonaute proteins couple chromatin silencing to alternative splicing (RNA IP-Seq) Refer to individual Series

2012-08-22 | E-GEOD-39749 | biostudies-arrayexpress

Comprehensive single cell transcriptional profiling of a multicellular organism by combinatorial indexing

Project description:Comprehensive single cell transcriptional profiling of a multicellular organism by combinatorial indexing

| PRJNA385514 | ENA